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Saliva Test for Early Identification of Gum Disease

Point-of-care salivary diagnostic test for periodontal disease staging and grading - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/109336
Enrollment
126
Registered
2026-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K053- Chronic periodontitis

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil Control Intervention1: Nil: Nil

Sponsors

Dr. Korukonda Jayavardhan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Systemically healthy individuals 2.Non-smokers or controlled smoking status as per group criteria 3.Group 1: Periodontally Healthy Interdental CAL: Absent Radiographic bone loss: None Probing pocket depth is less than or equal to 3 mm Tooth loss due to periodontitis: None Bone loss pattern: None Bleeding on probing: less than or equal 10 percent Disease progression (5 years): None Diabetes status: Normoglycemic 4.Group 2: Stage I Grade A Interdental CAL: 1 to 2 mm Radiographic bone loss: Coronal third (less than 15 percent) Probing pocket depth: less than or equal 4 mm Tooth loss due to periodontitis: None Bone loss pattern: Mostly horizontal Bleeding on probing: May be present Disease progression: No progression Bone loss/age ratio: less than 0.25 Smoking status: Non-smoker Diabetes status: Normoglycemic 5.Group 3: Stage II Grade A Interdental CAL: 3 to 4 mm Radiographic bone loss: Coronal third (15 33 percent) Probing pocket depth: less than or equal 5 mm Tooth loss due to periodontitis: None Bone loss pattern: Mostly horizontal Bleeding on probing: May be present Disease progression: No progression Bone loss/age ratio: less than 0.25 Smoking status: Non-smoker Diabetes status: Normoglycemic 6.Group 4: Stage II Grade B Interdental CAL: 3 4 mm Radiographic bone loss: Coronal third (15 33 percent) Probing pocket depth: less than or equal 5 mm Tooth loss due to periodontitis: None Bone loss pattern: Mostly horizontal Furcation involvement: Absent Ridge defects: Absent Disease progression (5 years): less than 2 mm Bone loss/age ratio: 0.25 1.0 Smoking status: less than 10 cigarettes per day Diabetes status: HbA1c less than 7 percent 7.Group 5: Stage III Grade B Interdental CAL: less than or equal 5 mm Radiographic bone loss: Middle third of root and beyond Probing pocket depth: less than or equal 6 mm Tooth loss due to periodontitis: less than or equal 4 teeth Bone loss pattern: Vertical bone loss greater than or equal 3 mm Furcation involvement: Class II or III Ridge defects: Moderate Disease progression (5 years): less than 2 mm Bone loss/age ratio: 0.25 1.0 Smoking status: less than 10 cigarettes per day Diabetes status: HbA1c less than or equal 7 percent 8.Group 6: Stage III Grade C Interdental CAL: greater than or equal 5 mm Radiographic bone loss: Middle third of root and beyond Probing pocket depth: greater than or equal 6 mm Tooth loss due to periodontitis: less than or equal 4 teeth Bone loss pattern: Vertical bone loss greater than or equal 3 mm Furcation involvement: Class II or III Ridge defects: Moderate Disease progression (5 years): greater than or equal 2 mm Bone loss/age ratio: greater than 1.0 Smoking status: greater than or equal 10 cigarettes per day Diabetes status: HbA1c greater than or equal 7 percent

Exclusion criteria

Exclusion criteria: 1.Pregnant women or those in the lactation period 2.Patients who had received systemic antibiotics and anti-inflammatory medication within the previous 6 months 3.Patients who had undergone periodontal treatment within the last 2 years 4.Individuals with systemic conditions influencing periodontal status, such as Diabetes mellitus 5.HIV-positive status 6.Patients with active dental caries or other oral infections

Design outcomes

Primary

MeasureTime frame
Evaluation of salivary parameters (pH, leukocytes, hemoglobin, nitrite, protein, glucose, ketone bodies, bilirubin, urobilinogen, and specific gravity) measured using the Combur-10 reagent strip among individuals with different stages and grades of periodontitis.Timepoint: Baseline

Secondary

MeasureTime frame
Evaluation of the usefulness of Combur-10 as a rapid point-of-care diagnostic adjunct in routine clinical practice.Timepoint: baseline

Countries

India

Contacts

Public ContactDr Mohan Kumar Pasupuleti

Vishnu Dental College

mosups@gmail.com7799411140

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026