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Comparison of two medicines (magnesium sulphate and dexmedetomidine) to safely lower blood pressure during sinus surgery (FESS) in adult patients

A randomized study to compare intravenous magnesium sulphate versus intravenous dexmedetomidine for controlled hypotension during elective functional endoscopic sinus surgery at SMS Medical College Jaipur - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109329
Enrollment
80
Registered
2026-04-24
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Hypotension in during endoscopic sinus surgery: Hypotension during different agents in endoscopic sinus surgery Intervention2: Intravenous Dexmedetomidine: Loading dose of 1 mcg per kg

Sponsors

SMS medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients giving written informed consent 2. Patients scheduled to undergo FESS under General Anaesthesia. 3. Patients having American Society of Anesthesiologist(ASA) physical status I and II. 4. Patients aged 18-60 years.

Exclusion criteria

Exclusion criteria: 1. Patients with hypersensitivity to the medication. 2. Patients with concurrent severe cardiovascular and respiratory condition General Haematological and neuromuscular diseases hypotension sinus bradycardia, chronic hypertension. 3. Patients with anticipated difficult intubation

Design outcomes

Primary

MeasureTime frame
Mean time in minutes required to achieve the target Mean Arterial Pressure of 60 to 70 mmHgTimepoint: Assessed continuously from the start of the study drug infusion until the exact minute the target pressure is first achieved—

Secondary

MeasureTime frame
1 Quality of surgical field assessed by mean bleeding score 2 Mean surgeon satisfaction score 3 Mean extubation time 4 Median Ramsay sedation score 5 Time to achieve recovery score of 9 or more 6 Mean numerical rating scale for pain 7 Mean time to require first rescue analgesic 8 Requirement of additional esmolol doses 9 Proportion of patients experiencing side effectsTimepoint: 1 Assessed at end of surgery 2 Assessed at end of surgery 3 Assessed at end of anaesthesia 4 Assessed postoperatively at 0 30 60 90 or 120 minutes 5 Assessed postoperatively at 0 30 60 90 or 120 minutes 6 Assessed postoperatively at 0 30 60 90 or120 minutes 7 Assessed postoperatively up to 120 minutes 8 Assessed continuously intraoperatively 9 Assessed continuously intraoperatively andpostoperatively up to 120 minutes—

Countries

India

Contacts

Public ContactDr Neelu Sharma

Sawai Man Singh Medical College And Attached Hospital

Drneelu13@gmail.com9782480455

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026