Health Condition 1: - Health Condition 2: O- Medical and Surgical Health Condition 3: M968- Other intraoperative and postprocedural complications and disorders of musculoskeletal system, not elsewhere classified
Conditions
Interventions
Intervention1: Intermittent epidural bolus: Epidural administration of 0.125 percent bupivacaine as intermittent bolus. Initial dose of 8 ml followed by 4 ml boluses as required for postoperative anal
Sponsors
Dr Nishith Govil Professor Department of Anaesthesia
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 55 to 80 years undergoing elective total knee replacement surgery. Patients requiring epidural analgesia for postoperative pain relief. ASA physical status I to III. Patients willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: Patients with history of epidural anesthesia complications such as epidural hematoma or infection. Known allergy to local anesthetics or study drugs. Patients with severe cardiovascular, renal or hepatic dysfunction. Patients with mental or cognitive impairment affecting pain assessment. Patients refusing consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative pain intensity measured using Visual Analog Scale at 12 hours, 24 hours, 48 hours and 72 hours after surgery.Timepoint: 12 hours, 24 hours, 48 hours and 72 hours after surgery. | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of hypotension, bradycardia and urinary retention within 72 hours after surgery.Timepoint: Up to 72 hours after surgery;Motor block assessed using Bromage scaleTimepoint: 12 hours, 24 hours, 48 hours and 72 hours after surgery | — |
Countries
India
Contacts
Public ContactDr Nishith Govil
Shri Guru Ram Rai Institute of Medical and Health Sciences
Outcome results
None listed