Testing if Hyaluronic Acid and an extract from blood together Improve Bone Healing Around dental Implants in the Upper Back Jaw: A Study Using Both Sides of the Mouth

The Efficiency of Hyaluronic acid with Platelet-Rich Fibrin (A PRF) on bone surrounding dental implants in posterior maxilla: a split-mouth randomized control trial - nil

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109274

Enrollment

Registered

2026-04-24

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Hyaluronic Acid With Platelet Rich Fibrin(A PRF): The blood is collected from the patient, and type A platelet-rich fibrin is obtained, and hyaluronic acid is mixed with the type A pla

Eligibility

Inclusion criteria

Inclusion criteria: Outpatients who have given informed consent are included in this study. The patients of age ranging from 25-50 years, include both males and females. without a history of systemic disease. Patients with bilaterally missing upper posterior teeth indicated for replacement. Patients with adequate bone volume for the dental implant procedure.

Exclusion criteria

Exclusion criteria: Patients with chronic smoking habits, alcohol and drug abuse. Patient with bleeding and clotting disease. Patients with metabolic and bone disease. Patients with liver disease.

Design outcomes

Primary

Measure	Time frame
To Assess The Bone Dimensional Changes Around The Dental Implants At Four Different Time PointsTimepoint: 0 days,30 days,90 days,180,days	—

Secondary

Measure	Time frame
To Evaluate The Osteoblatic activity around the dental implants with Hyaluronic acid and PRF with only PRF using scintigraphy at three different time pointsTimepoint: 15 days ,45 days, 90 days	—

Countries

India

Contacts

Public ContactDr Shanmuganathan Natarajan

sri ramachandra dental college

shanmuganathan.n@sriramachandra.edu.in9840231829

Outcome results