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Before giving propofol, patients are given either lignocaine or granisetron through the IV line. Then the doctor gives propofol and asks the patient how much pain they feel.

COMPARATIVE STUDY OF PREVENTION OF PROPOFOL INJECTION PAIN:PRETREATMENT WITH INTRAVENOUS 2% LIGNOCAINE 2ML VERSUS INTRAVENOUS GRANISETRON 2MG - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109264
Enrollment
60
Registered
2026-04-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N202- Calculus of kidney with calculus of ureter Health Condition 2: H701- Chronic mastoiditis Health Condition 3: E061- Subacute thyroiditis Health Condition 4: K420- Umbilical hernia with obstruction,without gangrene

Interventions

Intervention1: granisetron: 2ml of iv granisetron will be injected intravenously prior to giving injection propofol to reduce the pain of propofol injection Control Intervention1: 2% lignocaine preser

Sponsors

Dr Naga Seshu Kumari Vasantha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1.Patients undergoing elective surgeries under General Anesthesia. 2.Age between 18 to 60 years. 3.ASA Physical Status I and II. 4.Patients who give valid informed consent.

Exclusion criteria

Exclusion criteria: 1.Patient refusal. 2.History of allergy to Propofol, Lignocaine, or Granisetron. 3.Patients with difficult venous access. 4.Patients receiving analgesics or sedatives within 24 hours prior to surgery. 5.Pregnant or lactating women. 6.Hemodynamically unstable patients.

Design outcomes

Primary

MeasureTime frame
Incidence and severity of pain on Propofol injection, assessed using the Verbal Rating Scale (VRS) at 15 seconds after injection.Timepoint: Incidence and severity of pain on Propofol injection, assessed using the Verbal Rating Scale (VRS) at 15 seconds after injection.

Secondary

MeasureTime frame
NilTimepoint: Nil

Countries

India

Contacts

Public ContactDr Naga Seshu Kumari Vasantha

MVJ Medical college and Hospital

drseshu5@gmail.com06364899669

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026