Recognizing Efficacy and Safety of Syrup Nephrogrit in Patients with Chronic Kidney Disease (CKD).

To Evaluate the Efficacy and Safety of Syrup Nephrogrit in Patients with Chronic Kidney Disease (CKD) - Nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109253

Enrollment

150

Registered

2026-04-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N181- Chronic kidney disease, stage 1

Interventions

None listed

Eligibility

Inclusion criteria

Inclusion criteria: 1.Age- 30-65 Yrs 2.History of reduction of kidney function must be presented over 3 months or more. 3.Serum Creatinine level above 1.4 mg/dl and below 5.5 mg/dl 4.Serum Urea level above 40 mg/dl and below 150 mg/dl 5.Patient having Hb % more than 7.5 gm/dl 6.GFR 30-90ml/min./1.73m2 7.BUN (Blood Urea Nitrogen) above 18.6mg/dl and below 46.8mg/dl

Exclusion criteria

Exclusion criteria: 1.Age below 30 and above 65 years. 2.Serum Creatinine level below 1.4 mg/dl and above 5.5 mg/dl. 3.Serum Urea level below 40 mg/dl and above 150 mg/dl. 4.Patient having Hb % less than 7.5 gm/dl. 5.GFR beyond the limit of 30-90ml/min/1.73m2. 6.BUN (Blood Urea Nitrogen) below 18.6mg/dl and above 46.8mg/dl. 7.Patient having frequent repeated dialysis. 8.Uncontrolled Diabetes mellitus. 9.Malignant hypertension 10.Congenital disease of Kidney: Polycystic kidney disease. 11.Renal artery or vein obstruction 12.Liver failure 13 Pancreatitis 14.Sepsis 15.Prostate carcinoma 16.Grade-III Prostate 17.Heart Failure. 18.Transplant allograft failure 19.Microangiopathy like DIC, TTP 20.Systemic disease like SLE, lymphoma, leukaemia, sarcoidosis.

Design outcomes

Primary

Measure	Time frame
1.Change in Glomerular Filtration Rate (GFR) Measurement: eGFR calculated from serum creatinine 2.Change in Serum Creatinine Measurement: Serum creatinine (mg/dl) 3.Change in Blood Urea Measurement: Blood urea (mg/dl) 4.Change in Blood Urea Nitrogen (BUN) Measurement: BUN (mg/dl) Timepoint: 1- Serum Creatinine - (Baseline, Day 30, Day 60, Day 90) 2- Blood Urea - (Baseline, Day 30, Day 60, Day 90) 3- Glomerular Filtration Rate (GFR) - (Baseline, Day 30, Day 60, Day 90) 4- Blood Urea Nitrogen (BUN)- (Baseline, Day 30, Day 60, Day 90)	—

Measure

Time frame

1.Change in Glomerular Filtration Rate (GFR) Measurement: eGFR calculated from serum creatinine 2.Change in Serum Creatinine Measurement: Serum creatinine (mg/dl) 3.Change in Blood Urea Measurement: Blood urea (mg/dl) 4.Change in Blood Urea Nitrogen (BUN) Measurement: BUN (mg/dl) Timepoint: 1- Serum Creatinine - (Baseline, Day 30, Day 60, Day 90) 2- Blood Urea - (Baseline, Day 30, Day 60, Day 90) 3- Glomerular Filtration Rate (GFR) - (Baseline, Day 30, Day 60, Day 90) 4- Blood Urea Nitrogen (BUN)- (Baseline, Day 30, Day 60, Day 90)

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Secondary

Measure	Time frame
The following parameters were assessed at the indicated timepoints: 1.Symptom score: Composite score (0-3) of non-essential criteria (anemia, oliguria/anuria, burning micturition, pruritus, edema, thirst, difficulty in micturition) at baseline, Day 30, Day 60, and Day 90. 2.Hemoglobin level: Hb% and anemia grade at baseline and Day 90. 3.Urine parameters: Proteinuria/albuminuria and routine urine microscopy at baseline and Day 90. 4.Dialysis/renal replacement events: New dialysis initiation or hospitalization for renal failure during the study and 1-month follow-up. 5.Quality of life/patient global impression: Patient self-assessment (improved/unchanged/worse) at Day 90 and follow-up.Timepoint: Baseline, Day 30, Day 60, Day 90	—

Measure

Time frame

The following parameters were assessed at the indicated timepoints: 1.Symptom score: Composite score (0-3) of non-essential criteria (anemia, oliguria/anuria, burning micturition, pruritus, edema, thirst, difficulty in micturition) at baseline, Day 30, Day 60, and Day 90. 2.Hemoglobin level: Hb% and anemia grade at baseline and Day 90. 3.Urine parameters: Proteinuria/albuminuria and routine urine microscopy at baseline and Day 90. 4.Dialysis/renal replacement events: New dialysis initiation or hospitalization for renal failure during the study and 1-month follow-up. 5.Quality of life/patient global impression: Patient self-assessment (improved/unchanged/worse) at Day 90 and follow-up.Timepoint: Baseline, Day 30, Day 60, Day 90

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Countries

India

Contacts

Public ContactDr Ajay Kumar Tiwari

State Ayurvedic College and Hospital Lucknow

deepakwhynot@gmail.com9509074322

Outcome results