Comparing two treatment methods for termination of second trimester pregnancy with a live fetus in previous cesarean section patients

Termination of second trimester pregnancy with a live fetus in previous cesarean section patients: a randomized controlled clinical trial evaluating the comparative outcomes of two therapeutic regimens - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109199

Enrollment

100

Registered

2026-04-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O048- (Induced) termination of pregnancywith other and unspecified complications

Interventions

Intervention1: Double Dose MIFEPRISTONE with serial MISOPROSTOL: MIFEPRISTONE 200MG on DAY1 then repeat on DAY2 then from DAY3 onwards MISOPROSTOL 400MCG or 200MCG every 3 TO 4 hours until expulsion C

Eligibility

Inclusion criteria

Inclusion criteria: Prior one lower transverse cesarean section Singleton Pregnancy Second Trimester 13 to 27 weeks Scar Thickness more than or equal to 5mm by Trans abdominal Ultrasound Normally situated placenta UNFAVORABLE CERVIX BISHOP SCORE LESS THAN 5 INTACT FETAL MEMBRANES

Exclusion criteria

Exclusion criteria: Women with previous two or more uterine surgeries Classical cesarean section Congenital Uterine Abnormality Previous Rupture Uterus Uterine Fibroids Placenta Previa PREMATURE RUPTURE OF MEMBRANES AND SUSPECTED CHORIOAMNIONITIS UNDIAGNOSED VAGINAL BLEEDING MODERATE ANEMIA HEART DISEASE ANY CONTRAINDICATION TO MIFEPRISTONE OR MISOPROSTOL LIKE CHRONIC ADRENAL FAILURE OR ON IMMUNOSUPPRESSANT

Design outcomes

Primary

Measure	Time frame
Induction Abortion IntervalTimepoint: From MISOPROSTOL initiation to complete expulsion of fetus and placenta within 72 hours of induction	—

Secondary

Measure	Time frame
To determine & compare success rate of abortionTimepoint: within 72 hours of initiation of MISOPROSTOL;To determine & compare MISOPROSTOL dose requirementTimepoint: from initiation of MISOPROSTOL till delivery;To determine & compare side effects & complications in different protocolsTimepoint: During induction till discharge	—

Countries

India

Contacts

Public ContactRAGHUNATH BHATTACHARYYA

INSTITUTE OF POSTGRADUATE MEDICAL EDUCATION AND RESEARCH SSKM HOSPITAL KOLKATA

gynae07@gmail.com6290553205

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026