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Evaluation of efficacy of ketamine for prevention of chronic pain in patients with Lower Limb amputation.

COMPARSION OF CONVENTIONAL VERSUS MULTIMODAL PAIN MANAGEMENT PROTOCOL FOR THE PREVENTION OF PHANTOM LIMB PAIN AFTER LOWER LIMB AMPUTATION. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109150
Enrollment
88
Registered
2026-04-23
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M958- Other specified acquired deformities of musculoskeletal system

Interventions

Intervention1: Study group (Intravenous ketamine).: Study group will receive intravenous ketamine infusion at 0.15mg/kg/hr, will be continued post operatively for 48hrs. Control Intervention1: Compart

Sponsors

Geetanjali medical college and hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patient aged 18-75years including male and female. 2. Scheduled for unilateral elective lower limb amputation(Above or Below Knee). 3. ASA physical Status I-III. 4. Consenting Patients.

Exclusion criteria

Exclusion criteria: 1. Chronic Kidney Disease 2. History of Psychiatry illness affecting pain reporting. 3. Hypersensitivity or contraindication to study drugs. 4. Chronic Opioid use. 5. Pregnancy or Lactation.

Design outcomes

Primary

MeasureTime frame
To evaluate and compare the preoperative multimodal analgesic protocol with conventional protocol for the prevention of phantom limb pain in terms of severity of pain within 48hrs using VAS and Opioid consumption within 48hrs in terms of dosage, no. of dose and time of 1st rescue analgesic requirement. Incidence and severity of Phantom limb pain at 1,3,6 months post lower limb amputation using PPQ. Psychological parameters using HADS score and PCS score.Timepoint: To evaluate and compare the preoperative multimodal analgesic protocol with conventional protocol for the prevention of phantom limb pain in terms of severity of pain within 48hrs using VAS and Opioid consumption within 48hrs in terms of dosage, no. of dose and time of 1st rescue analgesic requirement. Incidence and severity of Phantom limb pain at 1,3,6 months post lower limb amputation using PPQ. Psychological parameters using HADS score and PCS score.—

Secondary

MeasureTime frame
To evaluate incidence of drug related adverse effects and Patient satisfaction with pain management.Timepoint: To evaluate incidence of drug related adverse effects and Patient satisfaction with pain management.—

Countries

India

Contacts

Public ContactTunga Bharathi

Geetanjali Medical College And Hospital

charusharma19@gmail.com7665794777

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026