Comparitive study of two medications (Epinephrine versus Phenylephrine) used to manage low blood pressure during intubation procedure.

Comparative study of Epinephrine versus Phenylephrine as Push-Dose Pressors for Peri-Intubation Hypotension - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109144

Enrollment

300

Registered

2026-04-23

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: Preloaded Syringe A with Inj Epinephrine 10 mcg per ml: The staff nurse would administer 1ml from preloaded syringe just before administration of induction agents this will constitute o

Eligibility

Inclusion criteria

Inclusion criteria: Age more than equal to 18 years All patients undergoing RSI in Emergency department

Exclusion criteria

Exclusion criteria: Age less than 18 years Not giving consent Pregnant patients Patients in cardiac arrest Perintubation SBP more than 90 mm Hg Patients with ongoing ventricular arrythmias Patients already intubated before presenting to ED

Design outcomes

Primary

Measure	Time frame
To compare the effect of Epinephrine and Phenylephrine as push dose pressors for peri intubation hypotension Timepoint: Responder Episodes that achieved a 25% increase in SBP at or before T4 will be classified as responder Non responder Episodes that achieved a 25% increase in SBP by T4 will be classified as non-responders T4 is defined as 10 min after giving first dose of PDP	—

Secondary

Measure	Time frame
To compare in hospital mortality within 1 weekTimepoint: 1 week mortality rate in both arms ;No of doses of PDP required in each group for responderTimepoint: No of doses of PDP required in each group for increasing SBP to more than 25 percent at T4;To compare the safety of PDP in the two groupsTimepoint: Record the PDP related adverse events in both the groups;To assess the requirement of continuous vasopressor support within 4 hours of PDP administrationTimepoint: Need of continuous vasopressor support within 4 hours of PDP administration;To compare incidence of cardiac arrest within 1 hour of PDPTimepoint: Incidence of cardiac arrest within 1 hour of PDP	—

Measure

Time frame

To compare in hospital mortality within 1 weekTimepoint: 1 week mortality rate in both arms ;No of doses of PDP required in each group for responderTimepoint: No of doses of PDP required in each group for increasing SBP to more than 25 percent at T4;To compare the safety of PDP in the two groupsTimepoint: Record the PDP related adverse events in both the groups;To assess the requirement of continuous vasopressor support within 4 hours of PDP administrationTimepoint: Need of continuous vasopressor support within 4 hours of PDP administration;To compare incidence of cardiac arrest within 1 hour of PDPTimepoint: Incidence of cardiac arrest within 1 hour of PDP

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Countries

India

Contacts

Public ContactDR IRTIQA SHEIKH

GANDHI MEDICAL COLLEGE

irtiqa.em@gmail.com8287995923

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026