Health Condition 1: -
Conditions
Interventions
Intervention1: Intralesional Platelet-Rich Plasma (PRP): Autologous platelet-rich plasma will be prepared from the patient s venous blood using standard centrifugation technique. The prepared PRP will
Sponsors
Dr Bijum Toko
Eligibility
Inclusion criteria
Inclusion criteria: Symptomatic cases of oral lichen planus burning sensation and pain. Age range from 18 to 70 years. Clinical and histopathological picture that suggests the diagnosis of oral lichen planus. Patients who give consent for the treatment
Exclusion criteria
Exclusion criteria: Thongprasom sign scoring, score 0 no lesions, normal mucosa. Asymptomatic patients. Systemic disorders hematological diseases, cardiovascular diseases, diabetes mellitus, hypertension. Platelet count less than 150,000 mm3 Hemoglobin less than 11g/dl. Pregnant or active breastfeeding females. Patients who had a lesion(s) with dysplasia. Patients with recent exposure to medications known to cause oral lichenoid reactions. Patients under anticoagulants or immunosuppression drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Reduction in pain and burning sensation assessed using Visual Analogue Scale at baseline and weekly intervals up to 4 weeksTimepoint: Reduction in pain and burning sensation assessed using Visual Analogue Scale at baseline and weekly intervals up to 4 weeks | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of efficacy between the two treatment groupsTimepoint: Change in clinical severity assessed using Thongprasom scoring system up to 12 weeks | — |
Countries
India
Contacts
Public ContactDr Ajay Parihar
Government College of Dentistry, Indore, M.P
Outcome results
None listed