Comparison of APRF plus and animal derived acellular dermal matrix in patients with thin gingival phenotype around dental implants to enhance the soft tissue

Comparative evaluation of A-PRF plus and xenogeneic Acellular Dermal Matrix for enhancing soft tissue in thin gingival phenotype around the dental implant sites- a clinical study. - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109043

Enrollment

Registered

2026-04-22

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K069- Disorder of gingiva and edentulousalveolar ridge, unspecified

Interventions

Intervention1: A-PRF plus: Advanced platelet rich fibrin plus (APRF plus) is placed at the facial/buccal aspect inside the flap and will be sutured during the implant placement at baseline and reviewe

Eligibility

Inclusion criteria

Inclusion criteria: 1. Subjects must be 18 to 65 years of age. 2. Fully healed bone sites. 3. Teeth adjacent to the selected edentulous site must be free of periodontal disease involvement. 4. Edentulous gap in any region of the mouth with minimum1mm distance range from adjacent tooth/teeth. 5. No medical contraindication for implant surgery. 6. Edentulous site of implant in any region of the mouth with less than 1.5 mm of mucosal tissue thickness. 7. Favourable occlusion relationship.

Exclusion criteria

Exclusion criteria: 1. Poor oral hygiene. 2. Symptoms or history of periodontitis or peri-implantitis treatment. 3. Smoker and alcoholic person. 4. Patients with systemic diseases. 5. Alveolar ridges with bone defects at implantation sites. 6. Subjects with acute infectious lesions in the areas intended for surgery. 7.Uncooperative patients

Design outcomes

Primary

Measure	Time frame
To evaluate the gain in peri implant soft tissue thickness in mm following augmentation with A-PRF PLUS and Xenogeneic acellular dermal matrix.Timepoint: All clinical parameters will be measured at baseline 3months 6months	—

Secondary

Measure	Time frame
To compare the efficacy of A-PRF PLUS and xenogeneic acellular dermal matrix in thin gingival phenotypeTimepoint: All clinical parameters will be measured at baseline 3months 6months	—

Countries

India

Contacts

Public ContactDr Amit K Walvekar

Coorg Institute of Dental Sciences

shashankgou341@gmail.com8892672416

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026