Comparing Healing of Gums and Bone Around Immediate Dental Implants Using Different Platelet-Based Treatments in Lower Back Teeth

Comparison of Hard & Soft tissue changes around Immediate Implant with bioactivation using Leukocyte-PRF,Injectable-PRF & Titanium-PRF in Mandibular Posterior Region: Randomized Controlled Trial - NIL

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/109035

Enrollment

Registered

2026-04-21

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K039- Disease of hard tissues of teeth,unspecified

Interventions

Intervention1: INJECTABLE-PRF: Step 1. Adequate local anaesthesia will be achieved for safe and painless surgical procedure . Step 2. Atraumatic tooth extraction preserving socket walls

minimal flap elevation (flapless approach preferred when possible), full thickness mucoperiosteal flap will be reflected. Step 3. Socket debridement & assessment Debridement of socket with sali

measure bone wallsand residual ridge Step 4. Implant osteotomy site preparation will be done using implant drills Step 5.Injectable-PRF coated implant fixture will be placed in osteotomy site,DFD

measure bone wallsand residual ridge Step 4. Implant osteotomy site preparation will be done using implant drills Step 5. Titanium-PRF coated implant fixture will be placed in osteotomy site,DFDB

Eligibility

Inclusion criteria

Inclusion criteria: 1. Systemically healthy patients 2. Grossly carious mandibular posterior teeth indicated for extraction without any periapical pathology with bone density ranging in D2-D3. 3. Adequate oral hygiene levels. 4. Patient who is willing to take part in study

Exclusion criteria

Exclusion criteria: 1.Patients with systemic diseases that contraindicated for the surgery, immuno-compromised patients. 2. H/o of Radiotherapy, smokers, parafunctional habits, tobacco consumers. 3. Pregnant or lactating females. 4. Patient diagnosed with Stage I-IV Grade A-C periodontitis.(2018 classification) 5. Patients not willing to participate in the study.

Design outcomes

Primary

Measure	Time frame
1. Implant Stability (RFA) 2. Crestal bone level (IOPA by Paralleling Technique using Grid) 3. Bone Density(CBCT)Timepoint: For Implant Stability and Crestal bone level at the time of placement,after 3 months of placement and after 6 months of placement	—

Secondary

Measure	Time frame
Landry et al Healing IndexTimepoint: Measured after 10 days of placement,after 1 month of placement,after 3 months of placement and after 6 months of placement.	—

Countries

India

Contacts

Public ContactDr Vaibhav Karemore

Government Dental College and Hospital,Nagpur

drperiodon@gmail.com9011098882

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026