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A study to evaluate the effect of the length of gastric myotomy and the development of acid reflux after peroral endoscopic myotomy (endoscopic surgery) for esophageal motility disorders (achalasia cardia type I, II and esophagogastirc junction outlet obstruction)

Relation Of Length of Gastric Myotomy and Occurrence of Gastroesophageal Reflux Disease after Peroral Endoscopic Myotomy for Achalasia Cardia Type I, II And Esophagogastric Junction Outflow Obstruction- A Double Blind Randomised Controlled Trial (RELATION Trial) - RELATION trial

Status
Recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109029
Enrollment
108
Registered
2026-04-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K80-K87- Disorders of gallbladder, biliary tract and pancreas

Interventions

Intervention1: 5 cm gastric myotomy: In this group the patients will undergo 5 cm gastric myotomy while undergo peroral endoscopic myotomy for achalasia cardia type I, II and esophagogastric junction

Sponsors

Post Graduate Institute of Medical Education and Research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Monometrically confirmed cases of achalasia cardia types I and II and esophagogastric junction outflow obstruction (EGJOO)

Exclusion criteria

Exclusion criteria: -Other spastic oesophageal motility disorders including achalasia cardia type III, distal esophageal spasm and jackhammer esophagus -Not willing for POEM -Severe coagulopathy -Contraindication for general anaesthesia -Informed consent not available

Design outcomes

Primary

MeasureTime frame
-To compare the occurrence of gastroesophageal reflux disease at 3 months between the 2 groupsTimepoint: 3 months—

Secondary

MeasureTime frame
-to compare clinical success at 3 month and 1 year -to compare the adverse events -to compare the occurrence of gastroesophageal reflux disease at 1 yearTimepoint: 1 year—

Countries

India

Contacts

Public ContactHarshal Mandavdhare

Post Graduate Institute of Medical Education and Research

btidip@gmail.com6001996571

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026