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A Study to See Whether Dexmedetomidine Reduces Eye Pressure Changes in Patients Undergoing Beating-Heart Bypass Surgery

Effect of Dexmedetomidine on Intraocular Pressure changes during off-pump Coronary Artery Bypass Grafting (OPCAB): A Prospective, Randomised, controlled study. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/109020
Enrollment
60
Registered
2026-04-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: O- Medical and Surgical

Interventions

Intervention1: dexmedetomidine: Loading dose: 1 mcg/kg over 10 minutes followed by Maintenance infusion: 0.5 mcg/kg/hour Infusion continued till end of surgery Control Intervention1: saline(placebo):

Sponsors

Sri jayadeva institute of cardiovascular sciences and research
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Triple vessel coronary artery disease Scheduled for elective OPCAB surgery

Exclusion criteria

Exclusion criteria:

Design outcomes

Primary

MeasureTime frame
To compare intraocular pressure changesTimepoint: T0 Before induction T1 30 minutes after induction T2 Prior to coronary anastomosis T3 End of left anterior descending artery anastomosis T4 End of left circumflex or posterior descending artery anastomosis (end of Trendelenburg position) T5 End of surgery—

Secondary

MeasureTime frame
To compare ocular perfusion pressure (OPPTimepoint: T0 Before induction T1 30 minutes after induction T2 Prior to coronary anastomosis T3 End of left anterior descending artery anastomosis T4 End of left circumflex or posterior descending artery anastomosis (end of Trendelenburg position) T5 End of surgery ;HRTimepoint: T0 Before induction T1 30 minutes after induction T2 Prior to coronary anastomosis T3 End of left anterior descending artery anastomosis T4 End of left circumflex or posterior descending artery anastomosis (end of Trendelenburg position) T5 End of surgery ;MAPTimepoint: T0 Before induction T1 30 minutes after induction T2 Prior to coronary anastomosis T3 End of left anterior descending artery anastomosis T4 End of left circumflex or posterior descending artery anastomosis (end of Trendelenburg position) T5 End of surgery ;CVP Timepoint: T0 Before induction T1 30 minutes after induction T2 Prior to coronary anastomosis T3 End of left anterior descending artery anastomosis T4 End of left circumflex or posterior descending artery anastomosis (end of Trendelenburg position) T5 End of surgery—

Countries

India

Contacts

Public ContactPraveen NB

Sri Jayadeva Institute of Cardiovascular Sciences & Research

prvnnb@gmail.com9619581468

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026