Health Condition 1: H160- Corneal ulcer
Conditions
Interventions
Intervention1: Participants will undergo cornea cross linking with Rose bengal 0.1% dye eye drops using Green light: 15 minutes in the study eye
Control Intervention1: Balanced salt solution will be i
Sponsors
Aravind Eye Hospital and Postgraduate Institute of Ophthalmology
Eligibility
Inclusion criteria
Inclusion criteria: 1) Presence of culture positive fusarium fungal keratitis 2) Age over 18 years 3) Moderate to severe vision loss, defined as Snellen visual acuity of 20/40 or worse 4) Corneal thickness 350 m as measured on AS OCT 5) Basic understanding of the study as determined by the physician 6) Commitment to return for follow up visits
Exclusion criteria
Exclusion criteria: 1) History of hypersensitivity to Rose Bengal 2) Evidence of concomitant infection on exam, gram stain, or confocal microscopy 3) History of intraocular surgery within the last three months 4) Impending or frank perforation at recruitment 5) Involvement of sclera at presentation 6) Presence of desmetocele at recruitment 7) Non-infectious or autoimmune keratitis 8) History of corneal transplantation 9) Pinhole visual acuity worse than 20/200 in the unaffected eye 10) Participants who are decisionally and/or cognitively impaired
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Improved visual acuity among those randomized to Rose Bengal Photo Dynamic Therapy after controlling for baseline visual acuity Timepoint: 3 MONTHS | — |
Secondary
| Measure | Time frame |
|---|---|
| There should be smaller infiltrate scar size and decreased rate of perforation and need for Therapeutic Penetrating Keratoplasty at 6 months among Rose Bengal Photo Dynamic Therapy treated participants Timepoint: 6 months | — |
Countries
Brazil, India, United States of America
Contacts
Public ContactDr N Venkatesh Prajna
Aravind Eye Hospital and PG Institute of Ophthalmology
Outcome results
None listed