A study comparing two ways of giving a sedative drug to keep heart rate and blood pressure stable during breathing tube insertion and to assess which method gives better stability and fewer side effects.

COMPARATIVE ANALYSIS OF NEBULIZED VS INTRAVENOUS DEXMEDETOMIDINE FOR BLUNTING THE HEMODYNAMIC RESPONSE TO LARYNGOSCOPY- A RANDOMIZED CONTROLLED STUDY - nil

Status

Active, not recruiting

Phases

Phase 2

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/108977

Enrollment

Registered

2026-04-21

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: R030- Elevated blood-pressure reading, without diagnosis of hypertension

Interventions

Intervention1: Nebulized Dexmedetomidine: Dexmedetomidine at a dose of 1 g/kg diluted in normal saline to a total volume of 4 5 ml, administered via nebulization 20 30 minutes prior to induction of g

Eligibility

Inclusion criteria

Inclusion criteria: 1.ASA I AND II 2.18-60 yrs age 3.Normal airway belonging to both genders undergoing elective surgeries under GA 4.Able to provide informed consent for participation

Exclusion criteria

Exclusion criteria: 1.Patients who were not consenting for the study 2.Predicted difficult airway 3.Pregnancy 4.Renal failure 5.Uncontrolled hypertension 6.Seizure disorder on antidepressant or antipsychotics 7.Patients with poor cardiopulmonary reserve and with BMI more than 30kg/m 8.Duration of scopy more than 15s 9.Two attempts at intubation

Design outcomes

Primary

Measure	Time frame
To compare the mean arterial pressure (MAP) between nebulised and intravenous dexmedetomidine groups following laryngoscopy and tracheal intubation for up to 10 minutes.Timepoint: baseline,during intubation ,1minutes,2minutes,3minutes,4minutes,5minutes,10 minutes following intubation	—

Secondary

Measure	Time frame
To assess preoperative sedation using the Ramsay Sedation Score (RSS) To determine the dose-sparing effect on the induction dose of propofol. To compare heart rate (HR) responses following laryngoscopy and intubation. To evaluate and record any side effects or adverse events in both groups. Timepoint: baseline ,during intubation,1minutes,2minutes,3minutes ,4minutes,5 minutes ,10 minutes following intubation	—

Measure

Time frame

To assess preoperative sedation using the Ramsay Sedation Score (RSS) To determine the dose-sparing effect on the induction dose of propofol. To compare heart rate (HR) responses following laryngoscopy and intubation. To evaluate and record any side effects or adverse events in both groups. Timepoint: baseline ,during intubation,1minutes,2minutes,3minutes ,4minutes,5 minutes ,10 minutes following intubation

—

Countries

India

Contacts

Public ContactDr Gifty Annie Thomas

Institute of Anaesthesiology Government Rajaji Hospital and Madurai Medical College

doctorvijaya@gmail.com9443774381

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026