Health Condition 1: J910- Malignant pleural effusion
Conditions
Interventions
Intervention1: talc + povidone-iodine: combining these two effective agents with inflammatory and sclerosing properties may be expected to enhance pleural symphysis, reduce recurrence of effusion, and
Sponsors
Dr Venkata Nagarjuna Maturu
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age greater than 18 years at the time of enrollment. 2.Diagnosed of malignant pleural effusion (MPE) by cytology or histology from pleural fluid or tissue. 3.Symptomatic effusion requiring intervention. 4.Expandable lung, demonstrated by chest radiograph or ultrasound after initial thoracentesis or fluid drainage. 5.Eastern Cooperative Oncology Group (ECOG) performance status of 0â??2. 6.Life expectancy greater than 3 months, as judged by the treating oncologist or pulmonologist. 7.Ability to provide written informed consent and comply with study procedures and follow-up.
Exclusion criteria
Exclusion criteria: 1.Known hypersensitivity to talc or povidone-iodine (betadine). 2.Trapped lung confirmed radiographically or via thoracic ultrasound. 3.Presence of active pleural infection (empyema). 4.Recent pleurodesis in past 7 days. 5.Severe coagulopathy not correctable. 6.Uncontrolled systemic infection or sepsis at the time of enrollment. 7.Pregnant or breastfeeding women. 8.Participation in another interventional trial involving pleural interventions that may interfere with outcomes.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Pleurodesis success Timepoint: Day 30 post-procedure | — |
Secondary
| Measure | Time frame |
|---|---|
| Extended pleurodesis success Dyspnea improvement Procedure-related adverse events Hospital stay durationTimepoint: 1.Extended pleurodesis success-Day 90 2.Dyspnea improvement-Day 3â??7, Day 30, and Day 90 3.Procedure-related adverse events-Within 3-7 days post-procedure 4.Hospital stay duration-Index hospitalization | — |
Countries
India
Contacts
Public ContactDr Venkata Nagarjuna Maturu
Yashoda Hospitals
Outcome results
None listed