Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: Nebulization with dexmedetomidine
: Participants will recieve calculated dose of dexmedetomidine at 1 microgram per kg in 5ml volume in nebulized form 15-20 minutes prior to induction
Sponsors
Department of Anesthesiology, IPGMER and SSKM Hospital
Eligibility
Inclusion criteria
Inclusion criteria: Patients aged 18 60 years of either sex, belonging to ASA physical status I and II, with Mallampati grade I and II, scheduled for elective surgery under general anesthesia requiring endotracheal intubation, with body mass index less than 30 kg/m , and willing to provide written informed consent.
Exclusion criteria
Exclusion criteria: Patients who do not provide consent for participation, those with ASA physical status other than I and II, Mallampati grade other than I and II, age less than 18 years or more than 60 years, body mass index (BMI) greater than 30 kg/m , known allergy to the study drugs (dexmedetomidine or magnesium sulphate), history of cardiovascular diseases such as ischemic heart disease, arrhythmias, tachycardia, bradycardia or uncontrolled hypertension, history of bronchial asthma, neuromuscular disorders, chronic alcohol intake or drug abuse, and pregnant patients will be excluded from the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To Study the change of Heart Beat / Min as a primary parameter by the effect of nebulized dexmedetomidine and magnesium sulphate during laryngoscopy and intubation.Timepoint: Baseline (T0), post-nebulization (T1), 2 minutes (T2), 5 minutes (T3), and 10 minutes (T4) after tracheal intubation | — |
Secondary
| Measure | Time frame |
|---|---|
| Change in systolic blood pressure (SBP)Timepoint: Baseline (T0), post-nebulization (T1), 2 minutes (T2), 5 minutes (T3), and 10 minutes (T4) after intubation;Change in diastolic blood pressure (DBP)Timepoint: Baseline (T0), post-nebulization (T1), 2 minutes (T2), 5 minutes (T3), and 10 minutes (T4) after intubation;Change in mean arterial pressure (MAP)Timepoint: Baseline (T0), post-nebulization (T1), 2 minutes (T2), 5 minutes (T3), and 10 minutes (T4) after intubation;Incidence of intraoperative adverse events (bradycardia, hypotension, respiratory depression)Timepoint: Intraoperative period;Incidence and severity of postoperative sore throatTimepoint: Immediately after extubation, 2 hours, 6 hours, and 24 hours postoperatively | — |
Countries
India
Contacts
Public ContactDr Bushra Khan
Institue of Post Graduate Medical Education and Reaserch and SSKM Hospital
Outcome results
None listed