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Clinical Comparison Of Two Platelet-Based Regenerative Treatments With Bone Graft In Patients With Bone Loss Around Multi-Rooted Teeth

Comparative Evaluation Of Titanium-Platelet Rich Fibrin (T-PRF) And Advanced-Platelet Rich Fibrin (A-PRF) With Demineralized Freeze-Dried Bone Allograft (DFDBA) In The Treatment Of Grade II Furcation Defects. - NIL

Status
Active, not recruiting
Phases
Phase 3Phase 4
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108922
Enrollment
22
Registered
2026-04-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K056- Periodontal disease, unspecified

Interventions

Intervention1: Test Group: Advanced- Platelet Rich Fibrin (A-PRF) with Demineralized Freeze- Dried Bone Allograft: Intervention: A-PRF +DFDBA in test group after elevation of a full thickness mucoperi

Sponsors

Sharad Pawar Dental College Sawangi Meghe Wardha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1) Mandibular Class II furcation defects. 2) Horizontal defect depth (HDD) should be less than or equal to 6 mm. 3) The vertical defect depth (VDD) should range from more than or equal to 3 mm and less than or equal to 6 mm. 4) Proximal bone height of the involved tooth should be coronal to the interradicular bones. 5) Adequate and present keratinized tissue should be present at least 2 mm from the mucogingival junction to the gingival margin. 6) The gingival margin of the involved tooth should be coronal to the fornix of the furcation defect. 7) Radiographic evidence of furcation defects buccal, mesiobuccal, distobuccal, and lingual.

Exclusion criteria

Exclusion criteria: 1. Patients who are not complying with the continuance of their periodontal maintenance treatment program. 2. Presence of smoking or tobacco habits. 3. Height of proximal bone of tooth involved is apical to interradicular bone heights. 4. Presence of mobility in the tooth to be involved. 5. Presence of any type of allergic reaction to materials used. 6. Presence of any previous or previous periodontal regeneration treatment in the chosen location or site. 7. Females who are either pregnant or lactating. 8. Presence of infectious diseases in patients such as hepatitis, HIV, or tuberculosis. 9. Patients who have had any type of systemic illness in their past.

Design outcomes

Primary

MeasureTime frame
Papillary Bleeding Index (PBI), Plaque Index (PI), Periodontal Pocket Depth (PPD), Relative Clinical Attachment Level (R-CAL), and Relative Gingival Marginal Level (R-GML).Timepoint: four months post operative

Secondary

MeasureTime frame
At four months following the surgical intervention, the clinical outcome will be measured by furcation height (FH), furcation width (FW), furcation depth (FD), horizontal defect depth (HDD), and vertical defect depth (VDD).Timepoint: After four months of surgery.

Countries

India

Contacts

Public ContactManali Prakash Sonavane

Datta Meghe Institute of Higher Education and Research

pavbajaj@gmail.com8412045019

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026