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Comparing the effectiveness of three medicament in the root canal against inflammatory mediators and their inhibitors in a single rooted tooth with inflammation and pain

Impact of three intracanal medicament on matrix metalloproteinases and their tissue inhibitors expression in acute apical periodontitis-An invivo study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108896
Enrollment
60
Registered
2026-04-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: LIQUORICE: 7.5% The intracanal medicaments will be placed after biomechanical preparation as per standard endodontic protocol. The medicament will be applied once per visit and left ins

Sponsors

RATHISH.R
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: BOTH MALE AND FEMALE PATIENT WHO CAME AS OUT PATIENT IN DEPARTMENT OF CONSERVATIVE DENTISTRY

Exclusion criteria

Exclusion criteria: PATIENTS WITH ALLERGY TO LOCAL ANAESTHESIA AND MEDICAMENTS PATIENT WITH SYSTEMIC DISEASE , PREGNANCY AND LACTATION TENDER ON PERCUSSION NEGATIVE PATIENT WITH NON RESTORABLE TOOTH

Design outcomes

Primary

MeasureTime frame
Reduction in MMP (e.g. MMP-2, MMP-9) levels and increase/modulation in TIMP levels in root canal samples.Timepoint: BASELINE 14TH DAY—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactDRASHOK LEBURU

KARPAGA VINAYAGA INSTITUTE OF DENTAL SCIENCES

ashokbds@gmail.com9884145541

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026