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Comparison of two root canal sealers for pain relief and healing in teeth with infection A Clinical study

Randomized Clinical Trial Comparing Post-operative Pain and Healing After Single-Visit Root Canal Treatment Using Bioceramic versus Epoxy Resin Sealers in Teeth with Apical Periodontitis - Nil

Status
Active, not recruiting
Phases
Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108861
Enrollment
60
Registered
2026-04-21
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Bioceramic sealer (BioRoot Flow): calcium silicate based bioceramic sealers exhibit superior biocompatibility, bioactivity, alkaline pH, and slight expansion on setting, which may posit
however, concerns persist regarding their initial cytotoxicity and polymerization shrinkage.

Sponsors

Alankrit Ranjan
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 years and above. Only one tooth per patient included. Teeth diagnosed with pulp necrosis and apical periodontitis. Mono-radicular or bi-radicular teeth. Patients without systemic diseases affecting healing. Teeth suitable for single-visit root canal treatment

Exclusion criteria

Exclusion criteria: Teeth with crack root fracture and root resorption Pregnant or Lactating women Immunocompromised Patient Teeth with periodontal probing depth more than 5mm Teeth with additional procedure such as crown lengthening

Design outcomes

Primary

MeasureTime frame
Postoperative PainTimepoint: Pain intensity will be assessed using the Heft Parker Visual Analog Scale HP VAS a 170-mm line with verbal descriptors ranging from no pain to maximum possible pain. Pain will be recorded at 6 hours 12 hours 24 hours 48 hours post-treatment

Secondary

MeasureTime frame
Radiographic HealingTimepoint: Standardized periapical radiographs will be taken at 3 and 6 months. Periapical healing will be assessed using the Periapical Index (PAI)

Countries

India

Contacts

Public ContactAlankrit Ranjan

Hitkarini Dental College

alankrit18111@gmail.com6266090557

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026