Health Condition 1: F102- Alcohol dependence
Conditions
Interventions
Intervention1: OM Chanting: OM chanting intervention will consist of thrice-a-day sessions. Each session will be done in a quiet comfortable environment. Participants will assume a comfortable sitting
O for 5 seconds, M for 10 seconds. A standardized pre-recorded audio guidance will be used for all OM-chanting sessions. The audio provides verbal cues for initiation and termination of each O an
each breath lasting for about 15 seconds. While chanting, participants will be encouraged to focus on the bodily sensations and their breathing. This session will last for 10 minutes. Participants may
Sponsors
Dr Deepak S Ghadigaonkar
National Institute of Mental Health and Neuro Sciences
Eligibility
Inclusion criteria
Inclusion criteria: 1. Diagnosis of Alcohol Use Disorder as per the Diagnostic and Statistical Manual- 5 TR. This diagnosis is made by expert clinicians working in the field of Addiction Psychiatry. Patients in an uncomplicated withdrawal state admitted to the Center for Addiction Medicine will be recruited. 2. Male sex: Most of the patients getting admitted to the Center for Addiction Medicine are male. Thus, the study participants will be limited to male clients. 3. Age:18-45 years. This age group has been chosen as increasing age is known to alter (usually decrease) the heart rate variability, which is the primary outcome measure. Older patients are also more likely to have a longer duration of alcohol use disorder and thus more likely to have complications related to alcohol use like alcoholic liver disease, alcoholic neuropathy, etc. Older patients also have higher prevalence of systemic diseases like hypertension which may alter HRV. 4. Willingness to participate in the study and provide informed consent
Exclusion criteria
Exclusion criteria: 1. History of complicated alcohol withdrawal in the past or currently getting admitted with complicated withdrawal 2. Comorbid seizure disorder 3. Comorbid other substance use disorder except for smoking 4. Comorbid medical conditions, viz., hypertension, diabetes mellitus, cardiac diseases including the history of angina pectoris or myocardial infarction in the past, severe liver or renal impairment (as guided by known parameters) 5. Cognitive impairment, which may impair the participation in the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the changes in heart rate variability in patients with alcohol use disorder who perform OM chanting (OM Intervention) during the treatment with those who do not (Hissing Intervention).Timepoint: T0 is at Day 1 of intervention. T1 is at Day 5 of intervention. T2 is 1 month after the 5 day intervention. T3 is 3 months after the 5 day intervention. | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the cortical silent period (CSP) measures using transcranial magnetic stimulation (TMS) in the two groups.Timepoint: T0 is at Day 1 of intervention. T1 is at Day 5 of intervention. T2 is 1 month after the 5 day intervention. T3 is 3 months after the 5 day intervention.;To compare serum cortisol levels in the two groupsTimepoint: T0 is at Day 1 of intervention. T1 is at Day 5 of intervention. T2 is 1 month after the 5 day intervention. T3 is 3 months after the 5 day intervention.;To compare the neuro-hemodynamic changes in the two groups using functional magnetic resonance imaging (fMRI)Timepoint: T0 is at Day 1 of intervention.;To compare the short-term outcomes in the two groups.Timepoint: T0 is 1 month after the 5 day intervention. T1 is 3 months after the 5 day intervention. | — |
Countries
India
Contacts
Public ContactDeepak S Ghadigaonkar
National Institute of Mental Health and Neuro Sciences (NIMHANS), Bengaluru.
Outcome results
None listed