A Clinical Study Comparing Two Siddha Purgation Therapies in Rheumatoid Arthritis Patients

COMPARATIVE EFFICACY OF AGASTHIYAR KUZHAMBU AND MURUKKANVITHAI MATHIRAI FOR PURGATION IN UTHIRAVATHA SRONITHAM (RHEUMATOID ARTHRITIS) PATIENTS : A RANDOMIZED CLINICAL STUDY FOCUSING ON VATHA PARAMETERS AND INFLAMMATORY BIO MARKERS - NIL

Status

Active, not recruiting

Phases

Phase 2Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/108794

Enrollment

Registered

2026-04-20

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M069- Rheumatoid arthritis, unspecified

Interventions

Intervention1: Agasthiyar Kuzhambu: 65 - 130 mg (1/2 - 1 kundri ) with Ginger extract or warm water / orally / Single dose Intervention2: Murukkanvithai Maathirai: 1 mathirai (Sundai alavu) with riped

Eligibility

Inclusion criteria

Inclusion criteria: Diagnosed cases of Rheumatoid Arthritis as per standard criteria Positive RA factor or Anti-CCP Elevated inflammatory markers (ESR and/or CRP above normal range) Those who are willing to participate

Exclusion criteria

Exclusion criteria: Pregnant and lactating women Recent steroid or biologic use (less than 4 weeks) Not willing to participate Patient with other arthritic condition

Design outcomes

Primary

Measure	Time frame
To compare the efficacy of Agasthiyar Kuzhambu and Murukkanvithai Maathirai as purgation therapy adjuncts to standard RA medications in reducing Vatha symptoms and siddha diagnostic markers like Naadi, Neikkuri and Manikkadai noolTimepoint: Day 0 (before purgation) Baseline Day 2 ( after purgation) Day 14, Day 28 and Day 48 Comparison	—

Secondary

Measure	Time frame
To assess the changes in inflammatory biomarkers ( ESR, CRP )Timepoint: Day 0 (before purgation) Baseline Day 2 ( after purgation) Day 14, Day 28 and Day 48 Comparison	—

Countries

India

Contacts

Public ContactDr S Sundararajan MD S

Government siddha medical college and hospital palayamkottai Tirunelveli

soundsundar12@gmail.com9443423937

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026