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A study comparing two types of nerve block injections for pain relief after knee replacement surgery in adults

Comparison of the Modified 4 in 1 block versus IPACK plus adductor canal block for post operative analgesia in total knee arthroplasty: A Randomized Comparative Study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108778
Enrollment
74
Registered
2026-04-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M17- Osteoarthritis of knee

Interventions

Intervention1: Modified 4-in-1 block: Patient supine, leg externally rotated and slightly flexed. Using ultrasound and PNS guidance, inject Bupivacaine 0.5% + Dexmedetomidine 1 g/kg (total 40 mL).

Sponsors

Dr Sivashankari P
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: ASA physical status I III, Undergoing elective unilateral Total Knee Arthroplasty, Willing to provide written informed consent

Exclusion criteria

Exclusion criteria: Coagulopathy or bleeding disorders, Local infection at injection site, Allergy to local anaesthetic drugs, Cognitive or psychiatric disorders, Neuropathy or neurological deficit, Chronic opioid use within last 3 months, Bilateral TKA or additional procedures, Severe cardiovascular, hepatic, renal, or respiratory disease, Pregnant patients.

Design outcomes

Primary

MeasureTime frame
To assess and compare postoperative pain scores using the Visual Analogue Scale (VAS) after surgery between the two groups.Timepoint: At 3, 6, 12, and 24 and 48 hours after surgery

Secondary

MeasureTime frame
1.To compare postoperative haemodynamic parameters (heart rate, blood pressure, oxygen saturation) between both groups. 2.To assess the requirement and timing of rescue analgesia in both groups. 3.To record and compare postoperative complications (e.g., muscle weakness, nausea, vomiting, infection) 4. To evaluate overall patient satisfaction with pain management.Timepoint: Intraoperative and postoperatively till 48 hours after surgery

Countries

India

Contacts

Public ContactDr Balamurugan MD

Institute of Anaesthesiology ,Madurai medical college

mbalan75@gmail.com9443135904

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026