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Can vaginal probiotic supplementation improve pregnancy rates in women undergoing Frozen embryo transfer

Effectiveness of intravaginal lactobacilli supplementation in success of assisted reproductive technology(ART) outcome before frozen embryo transfer. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108768
Enrollment
50
Registered
2026-04-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N979- Female infertility, unspecified

Interventions

Intervention1: Evabiom: 1 tablet containing atleast 1 billion colony forming units of mixed L.brevis CD2 50 percent L.salivarius FV2 30 percent L.plantarum FV9 18.75 percent Inserted intra vaginally

Sponsors

Jawaharlal nehru medical college wardha
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Women aged 21 to 50 years undergoing frozen thaw embryo transfer cycles

Exclusion criteria

Exclusion criteria: Endometrial thickness less than 7mm Allergy to medicine used in study group Embryo transfer not performed due to no survived embryo Waiting for surgery or large endometrial polyp Receiving antibiotics Lost to follow up

Design outcomes

Primary

MeasureTime frame
Clinical pregnancy rate defined as number of patients with visible gestational sac with cardiac activity on transvaginal sonography per total number of patients who received embryo transferTimepoint: 6 to 8 weeks after embryo transfer

Secondary

MeasureTime frame
Implantation rate defined as number of gestational sacs per number of embryos transferredTimepoint: At the time of first TVS after embryo transfer;Biochemical pregnancy rate defined as serum beta hCG more than 25 mIU per mL at 14 days post embryo transferTimepoint: 14 days after embryo transfer;Live birth rate defined as number of patients with live birth per total patients who received embryo transferTimepoint: At delivery;Change in vaginal microbiota profile assessed by Nugent score before and after interventionTimepoint: Before and after 6 days of Evabiom supplementation

Countries

India

Contacts

Public ContactDr Laxmi Siddu Gadadani

Jawaharlal Nehru Medical College,Wardha

deepti_shrivastava69@yahoo.com9860817801

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026