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Enhancing Gum Bone Regeneration: Do Bone Grafts Work Better With i-PRF?

Comparative Evaluation of the Efficacy of Allograft Alone and Allograft Combined with i-PRF in the Treatment of Periodontal Infrabony Defects: A Randomized Controlled Clinical Trial - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108667
Enrollment
20
Registered
2026-04-20
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Nil: Nil Intervention2: i-prf: i-prf from patient blood Intervention3: allograft: TATA memorial allograft Control Intervention1: Allograft, i-prf: TATA Memorial Allograft , i-prf from p

Sponsors

J.N Kapoor D.A.V Centenary Dental College
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients, who are cooperative, motivated and committed. Patients with 20 - 55 years. Patients with at least two teeth with periodontal probing depth (PD) More than or equal to 6 mm when measured using a manual periodontal probe (UNC 15) and CAL more than or equal to 5 mm. Radiographic presence of at least one infrabony osseous defect having depth equal or more than 3 mm. Patients who will have full-mouth plaque score (FMPS) and full-mouth bleeding score (FMBS) more than or equal to 20%.

Exclusion criteria

Exclusion criteria: Patients with any known systemic disease or conditions and drug or medication intake that will interfere with wound healing or minor surgical procedures. Patients who will be active smokers or consuming any other form of tobacco and not willing to quit. Patients allergic to any drug and/or material, used in the study. Patients unable or unwilling to undergo surgical procedure and uncooperative. Teeth with furcation defects, prosthesis, mobility more than or equal to Grade II. Patient who has undergone periodontal therapy in last 6 months.

Design outcomes

Primary

MeasureTime frame
primary outcome A) Clinical Parameter- 1. Clinical attachment level (CAL) B) Radiographic parameters- 1.Defect depth 2.Amount of defect fill 3.Amount of defect resolutionTimepoint: baseline , 12 weeks , 24 weeks

Secondary

MeasureTime frame
secondary outcome Clinical Parameters- Plaque index (PI) Bleeding index (BI) Pocket depth (PD)Timepoint: baseline , 12 weeks , 24 weeks

Countries

India

Contacts

Public ContactDr Pragati Chauhan

J.N. Kapoor, D.A.V Centenary Dental College

drdeepikab17@gmail.com9466302335

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026