Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: opioid-free anaesthesia: A multimodal anaesthetic technique that avoids intraoperative opioid use by employing non-opioid agents such as dexmedetomidine, ketamine, lidocaine, magnesium
Sponsors
SRM Medical College And Hospital and Research centre
Eligibility
Inclusion criteria
Inclusion criteria: Age 18 65 years ASA Physical Status 1 and 2 Patient undergoing general anesthesia (mastoidectomy)
Exclusion criteria
Exclusion criteria: Patients with a known allergy or hypersensitivity to opioids. History of psychiatric disorders Patients on chronic opioid therapy or long-term magnesium supplementation. Pregnant or lactating women. Patients with pre-existing cognitive impairment or neurodegenerative diseases Infections or inflammatory diseases that can confound biomarker analysis
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Change in inflammatory and neuroplasticity-related gene expression levelsTimepoint: Baseline, End of surgery and 24 hours after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative pain scores Total postoperative opioid consumption Incidence of postoperative nausea and vomiting (PONV) Post-Anesthesia Recovery Score Timepoint: Preoperative baseline, End of surgery, 24 hours postoperative | — |
Countries
India
Contacts
Public ContactAnto livin A V
SRM Medical College, Hospital and Research Centre
Outcome results
None listed