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Comparison of different methods to assess fluid requirement in critically ill patients on mechanical ventilator

Comparison of the Efficacy of Pulse pressure variation (PPV) Inferior vena cava distensibility (IVCd) Left ventricular outflow tract Velocity time integral(LVOT-VTI) for Predicting Fluid Responsiveness in Critically Ill Mechanically Ventilated Patients Observational Cohort study - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/108597
Enrollment
51
Registered
2026-04-17
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I998- Other disorder of circulatory system

Interventions

Intervention1: Nil: Nil

Sponsors

Mahatma Gandhi Medical College and Research Institute
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Age more than 18 years of age Passive leg raise PLR with a more than or equal to 10 percent increase in mean arterial pressure (MAP) from baseline value. Hemodynamically unstable patients requiring mechanical ventilation. Acute circulatory failure patient for which the decision was taken to administer fluids. Presence of at least one clinical sign of inadequate tissue perfusion defined as Systolic blood pressure less than 90 mmHg or mean arterial pressure less than 65 mmHg The need of vasopressor drugs Urine output less than 0.5 mLperkgperhour for atleast two hours Tachycardia heart rate more than 100perminute Serum lactate more than 2 mmolperLitre

Exclusion criteria

Exclusion criteria: Patients with irregular cardiac rhythm or having frequent ectopics Patient with acute respiratory distress syndrome (ARDS) Valvular heart disease: Significant aortic or mitral valve lesions Spontaneously breathing patients Renal patient with oliguria and volume overload Poor ECHO window Congenital Heart disease Need of more than 2 vasopressors

Design outcomes

Primary

MeasureTime frame
Prediction of fluid responsiveness using pulse pressure variation, inferior vena cava distensibility and left ventricular outflow tract velocity time integralTimepoint: Assessment of ability of pulse pressure variation, inferior vena cava distensibility and left ventricular outflow tract velocity time integral at Baseline before fluid challenge, and after fluid challenge at 15 minutes,30 minutes,45 minutes,60 minutes.—

Secondary

MeasureTime frame
changes in HR,MAP,Urine output & vasopressor requirement after fluid challengeTimepoint: Assessment of ability of pulse pressure variation, inferior vena cava distensibility & left ventricular outflow tract velocity time integral at Baseline before fluid challenge & after fluid challenge at 15 minutes,30 minutes,45 minutes,60 minutes.—

Countries

India

Contacts

Public ContactHemanth Kumar

MAHATMA GANDHI MEDICAL COLLEGE AND RESEARCH INSTITUTE

drvrhk@gmail.com9003550553

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026