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Comparison of Different Local Anaesthesia Techniques for Pain Control in Upper First Molar Teeth with Severe Tooth Pain

A parallel-arm randomized clinical trial evaluating the efficacy, injection pain, onset time, and duration of action of conventional 4 perctent articaine versus buffered 4 percent articaine versus buffered 4 percent articaine with palatal infiltration in patients with symptomatic irreversible pulpitis of maxillary first molars - nil

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108595
Enrollment
68
Registered
2026-04-17
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K040- Pulpitis

Interventions

Intervention1: Buffered 4 Percent Articaine: 4 Percent Articaine with 1:100000 epinephrine (1.8 mL) buffered with 0.18 mL of 8.4 Percent sodium bicarbonate immediately before administration. Given as

Sponsors

DR KARAN C
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 to 65 years with good general health, presenting with symptomatic irreversible pulpitis in maxillary first molar, having moderate to severe pain based on visual analogue scale, and willing to provide informed consent.

Exclusion criteria

Exclusion criteria: Patients with systemic diseases, presence of active infection at injection site, presence of periapical pathology, allergy to local anesthetics or sulfites, contraindication to epinephrine, pregnancy, intake of analgesics within past 12 hours, and pain in teeth other than maxillary first molar.

Design outcomes

Primary

MeasureTime frame
Anesthetic successTimepoint: During Access Cavity Preparation[15-20 Minutes After Injection]

Secondary

MeasureTime frame
Pain during injection measured using Heft-Parker Visual Analog Scale (VAS)Timepoint: Immediately during injection (needle insertion, placement and deposition);Onset time of anesthesiaTimepoint: Time from injection to loss of response to cold test (assessed at 5,10,15 minutes);Duration of anesthesiaTimepoint: Time from onset of anesthesia until return of sensation as reported by patient;Need for supplemental anesthesiaTimepoint: During endodontic procedure if pain is reported

Countries

India

Contacts

Public ContactKaran

Scb dental college and hospital

dr.subasish@gmail.com9937034576

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026