A study to compare the effect of two treatment options (minocycline gel plus adapalene gel versus clindamycin gel plus adapalene gel) in patients suffering from acne

Effectiveness, safety and tolerability of minocycline gel 4% with adapalene gel 0.1% versus clindamycin phosphate gel 1% with adapalene gel 0.1% in patients with mild to moderate acne vulgaris : an investigator blinded randomized clinical trial - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/108582

Enrollment

Registered

2026-04-17

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L700- Acne vulgaris

Interventions

Intervention1: Minocycline gel 4% and adapalene gel 0.1%: Minocycline gel 4% to be applied twice daily and adapalene gel 0.1% to be applied once daily at bedtime Control Intervention1: Clindamycin pho

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 years and above, diagnosed with mild to moderate acne vulgaris

Exclusion criteria

Exclusion criteria: 1. Patients with severe systemic diseases. 2. Patients with facial sunburn. 3. Pregnant and lactating females. 4. Patients allergic to tetracycline-class drugs. 5. Patients with clinically significant hepatic impairment. 6. Patients using systemic antibiotics. 7. Patients receiving any investigational therapy within 28 days of screening

Design outcomes

Primary

Measure	Time frame
Changes in inflammatory and non inflammatory lesion countTimepoint: Week 0, week 3, week 6, week 9, week 12	—

Secondary

Measure	Time frame
Change in Global acne grading score (GAGS)Timepoint: Week 0, week 3, week 6, week 9, week 12	—

Countries

India

Contacts

Public ContactDr Ananya Dawn

KPC Medical College and Hospital

mail2ananyadawn@gmail.com9564575632

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026