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Patients needing root canal treatment: comparison of three intracanal medicines to reduce infection-causing bacteria

Comparative Evaluation of Antibacterial Efficacy of Graphene Oxide, Triple Antibiotic Paste and Calcium Hydroxide as Intracanal Medicaments An In Vivo study - NIL

Status
Active, not recruiting
Phases
Phase 2Phase 3
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108549
Enrollment
60
Registered
2026-04-16
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K045- Chronic apical periodontitis

Interventions

Intervention1: Root Canal Treatment: To use triple antibiotic paste , graphene oxide in combination with double antibiotic paste, and calcium hydroxide in combination with chlorhexidine as intracanal

Sponsors

Government Dental college and hospital Ahmedabad
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 60 years requiring multi-visit endodontic treatment Permanent posterior teeth Teeth with closed apex.

Exclusion criteria

Exclusion criteria: Teeth with abnormally curved ,dilacerated root,calcified canals. Patients with history of allergy and systemic conditions Teeth with open apex, periodontally compromised teeth. Previously root canal treated teeth

Design outcomes

Primary

MeasureTime frame
All medicaments are expected to significantly reduce bacterial load. Graphene oxide with double antibiotic paste may show the greatest bacterial reduction, followed by triple antibiotic paste and calcium hydroxide with chlorhexidineTimepoint: baseline and 7 days

Secondary

MeasureTime frame
All medicaments are expected to significantly reduce bacterial load. Graphene oxide with double antibiotic paste may show the greatest bacterial reduction, followed by triple antibiotic paste and calcium hydroxide with chlorhexidineTimepoint: 7 days

Countries

India

Contacts

Public ContactDr Geeta Asthana

Government Dental College and Hospital Ahmedabad

geetasthana@gmail.com9824440656

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026