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Clinical Comparison of a Hesperidin-Containing Dental Adhesive with a Conventional Adhesive for Treating Cavities Near the Gum Line

Clinical Evaluation of a Hesperidin Incorporated Self-Etch Adhesive in Class V lesions: A Split-Mouth Study - HESPER Trial

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108547
Enrollment
33
Registered
2026-04-16
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Hesperidin incorporated self etch adhesive: 2% hesperidin in the self etch adhesive will be obtained by incorporating the Hesperidin/Dimethyl sulfoxide into 3M ESPE Universal self etc

Sponsors

Dr Mrudula Santosh Chaukaskar
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Teeth with class V lesions on both right as well as left side (atleast 1 on each side) 2. Antagonist teeth should be present 3. Participants must have good general health 4. Participants must be older than 18 years old 5. Participants should have an acceptable oral hygiene level. 6. At least 24 teeth under occlusion should be present. 7. Participants with abrasive lesions coronal to cemento-enamel junction 8. Class V lesions involving enamel and dentin 9. Participants having sensitivity

Exclusion criteria

Exclusion criteria: 1. Participants who do not have minimum of 1 Class V lesion on both sides 2. Participants who do not have normal molar occlusal relationship 3. Participants with periodontal disease 4. Participants who are not willing to participate 5. Participants with erosive lesions 6. Participants with abrasive lesion apical to cemento-enamel junction

Design outcomes

Primary

MeasureTime frame
The primary clinical endpoint is marginal integrity and retention & fracture.Timepoint: Baseline, 24 hours, 1 week, 6 months

Secondary

MeasureTime frame
The following secondary endpoints will also be evaluated: marginal staining, marginal adaptation, postoperative sensitivity, and secondary caries.Timepoint: Baseline, 24 hours, 1 week, 6 months

Countries

India

Contacts

Public ContactDr Mrudula Santosh Chaukaskar

Bharati Vidyapeeth Dental College & Hospital, Pune.

aniket.jadhav@bharatividyapeeth.edu9890100866

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026