Health Condition 1: T630- Toxic effect of snake venom
Conditions
Interventions
Intervention1: Low Dose Anti Snake Venom: Patients with Common Krait envenomation who are enrolled in Intervention arm will receive initial dose of 6 vials of Indian Polyvalent Antisnake Venom over 30
Sponsors
Postgraduate Institute of Medical Education and Research PGIMER
Eligibility
Inclusion criteria
Inclusion criteria: 1.Age more than 12 years 2.Clinical diagnosis of common krait envenomation 3.Neuroparalytic manifestations attributable to snake envenomation. 4.Snakebite to initiation of ASV therapy less than or equal to 12 hours
Exclusion criteria
Exclusion criteria: 1.Evidence of hemotoxic envenomation (abnormal 20-minute WBCT or laboratory-confirmed coagulopathy) 2.Prominent local swelling or necrosis suggestive of cobra envenomation 3.Dry or incomplete bite without neurotoxicity 4.Completed ASV treatment in an outside hospital 5.Refusal of consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ventilator free days at day 7 (VFD7)Timepoint: Day 7 after enrolment | — |
Secondary
| Measure | Time frame |
|---|---|
| Time to recovery from neurotoxic paralysis defined as sustained resolution of bulbar ocular limb & respiratory muscle weaknessTimepoint: Up to discharge from hospital;Total hospital length of stay in daysTimepoint: At hospital discharge;In hospital mortalityTimepoint: During hospital stay;Antivenom related adverse reactions including acute hypersensitivity reactions & delayed reactionsTimepoint: During hospital stay | — |
Countries
India
Contacts
Public ContactDr Ashok Kumar Pannu
Post Graduate Institute of Medical Education and Research, Chandigarh
Outcome results
None listed