Health Condition 1: J22- Unspecified acute lower respiratory infection
Conditions
Interventions
Intervention1: HOLIDAY METHOD: Children aged 1 59 months with respiratory distress, will be screened for initiation of HFNC therapy based on Clinical Respiratory Distress Score (CRS) more than or equa
Sponsors
MADHUSUDAN S
Eligibility
Inclusion criteria
Inclusion criteria: 1. Age from 1 month to 5 years. 2. Initiated on HFNC for acute respiratory distress/failure. 3. Diagnosed with Bronchiolitis or Pneumonia or viral triggered wheeze. 4. The treating clinician considers the patient ready for weaning. 5. Informed consent obtained from legal guardian.
Exclusion criteria
Exclusion criteria: 1. Post extubation 2. Escalation to NIV/IMV before weaning 3. Persistent Pneumonia 4. Empyema 5. Asthma 6. Congenital/Acquired heart disease 7. Chronic Lung disease(Bronchopulmonary dysplasia, Cystic fibrosis, Primary Ciliary Dyskinesia, Congenital lung malformation, Bronchiectasis) 8. Congestive cardiac failure 9. Chronic neurological/neuromuscular disease 10. Chronic kidney disease 11. Airway anomaly/malacia 12. Malignancy/Post transplant/Immunocompromised 13. Home-ventilation/oxygen dependence. 14. Refusal to consent
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare length of PICU stayTimepoint: Till PICU discharge or transfer out to ward or death | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare duration of HFNC therapy in hours from initiation of weaning to transition to standard oxygen therapy.Timepoint: Time points from weaning to transition to standard oxygen therapy;To compare duration of total HFNC useTimepoint: Time from initiation to stopping of HFNC;To compare length of hospital stayTimepoint: Till hospital discharge or death;To compare rate of weaning failure, that is, re-initiation of HFNC or escalation to non-invasive ventilation or invasive mechanical ventilation within 24 hours post weaning attempt.Timepoint: 24 hours post weaning attempt;To compare time from initiation of weaning to weaning failure.Timepoint: Till the time of weaning failure , that is re-initiation of HFNC or escalation to non invasive or invasive mechanical ventilation;To assess safety outcomesTimepoint: Whole study period especially during the time of HFNC theray;To compare mean oxygen consumption between the two groups that is HFNC flow multiplied by hoursTimepoint: From initiation to stopping of HFNC | — |
Countries
India
Contacts
Public ContactAnanya Shriyam
ALL INDIA INSTITUTE OF MEDICAL SCIENCES, BIBINAGAR
Outcome results
None listed