A study to compare how well melatonin and prednisolone work in controlling pain after wisdom tooth removal.

Randomised control trial : To evaluate the efficacy of preoperative melatonin vs prednisolone in postoperative pain management after mandibular 3rd molar extraction. - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/108378

Enrollment

Registered

2026-04-15

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K011- Impacted teeth

Interventions

Intervention1: Tablet Melatonin 10mg: Tablet Melatonin 10mg single dose via Oral Route as premedication. To be administered 1 hour before procedure Control Intervention1: Tablet Prednisolone 20mg: Tab

Eligibility

Inclusion criteria

Inclusion criteria: Age more than 18 years Bilateral class II position B type of impacted mandibular 3rd molars Willing to give consent

Exclusion criteria

Exclusion criteria: Pregnant women Patients with systemic disease or condition that impairs healing

Design outcomes

Primary

Measure	Time frame
Post operative pain and swellingTimepoint: Post operative pain and swelling after after 48 hours and after 1 week	—

Secondary

Measure	Time frame
Perioperative anxietyTimepoint: Just before starting procedure;Post operative need for rescue medicineTimepoint: after 48 hours after 1 week;Post operative mouth openingTimepoint: after 48 hours after 1 week	—

Countries

India

Contacts

Public ContactAakash Kardile

All India Institue of Medical sciences New Delhi

drrahulomfs@gmail.com9999994578

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026