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Tumor Inflammation shows oral cancer secrets in untreated oral cavity cancer undergoing surgery

EXTENT OF TUMOR ASSOCIATED INFLAMMATION AS AN INDICATOR OF THE TUMOR MICROENVIRONMENT AND ITS CLINICOPATHOLOGICAL CORRELATES IN PREVIOUSLY UNTREATED ORAL CAVITY CANCER - Nil

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/108300
Enrollment
100
Registered
2026-04-13
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: - Health Condition 2: C029- Malignant neoplasm of tongue, unspecified

Interventions

Intervention1: Nil: Nil Intervention2: Nil: Nil Intervention3: Nil: Nil

Sponsors

Dr Aseem Mishra
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1 Patients aged above 18 years 2 Histologically confirmed cases of oral squamous cell carcinoma 3 Treatment na ve patients scheduled for primary surgical resection 4 Availability of complete clinicopathological data including demographic details tumor site size stage grade and margin status

Exclusion criteria

Exclusion criteria: 1 Patients not willing to participate 2 Patients who have received neoadjuvant chemotherapy or radiotherapy 3 Cases presenting with recurrent or metastatic OSCC 4 Patients with non squamous malignancies of the oral cavity

Design outcomes

Primary

MeasureTime frame
To analyze the relationship between the extent of inflammation and key clinicopathological parameters including tumor site, size, histological grade, depth of invasion, T and N stage, perineural invasion, lymphovascular invasion, and margin statusTimepoint: 4 weeks—

Secondary

MeasureTime frame
To examine the inflammatory infiltrates like lymphocytes neutrophils and eosinophils in tumor surgical marginsTimepoint: 18 months—

Countries

India

Contacts

Public ContactDr Aseem Mishra

Mahamana Pandit Madan Mohan Malviya Cancer centre, Varanasi

draseemmishra@gmail.com8080611946

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026