Health Condition 1: A309- Leprosy, unspecified
Conditions
Interventions
Intervention1: Methylene blue-activated Photodynamic therapy: In addition to current standard of care, Methylene blue (1% concentration) will be applied to the ulcer site for 10-20 seconds and treated
Sponsors
The Leprosy Mission Trust India
Eligibility
Inclusion criteria
Inclusion criteria: An ulcer in anaesthetic limb due to leprosy, Ulcers deeper to skin (going past the dermis), Growth of microorganisms on culture from the ulcer
Exclusion criteria
Exclusion criteria: Vascular diseases Chronic venous insufficiency, absent distal pulses, Undernutrition (BMI less than 18), Anaemia (less than 8g/dl), Patients on immunosuppressive medications (corticosteroids and others), Pregnant women, Patients tested to be positive for HIV, HBsAg & HCV.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microbial load after PDTTimepoint: Weekly once until end point | — |
Secondary
| Measure | Time frame |
|---|---|
| Bates Jensen scoreTimepoint: Weekly once until end point;The size of the ulcer (healing rate)Timepoint: Weekly once until end point;Growth of pathogenTimepoint: Weekly once until end point;Adverse events which occur due to the interventionTimepoint: At the time the event occurs;Acceptability of the interventionTimepoint: At the end point | — |
Countries
India
Contacts
Public ContactKarthikeyan Govindasamy
The Leprosy Mission Trust India
Outcome results
None listed