Health Condition 1: O- Medical and Surgical
Conditions
Interventions
Intervention1: injection ketofol: combination drug (ketamine and propofol) 1:5
Patients will receive a ketofol infusion prepared by mixing 40 mL of propofol (10 mg/mL) with 8 mL of ketamine (10 mg/mL)
Sponsors
All India Institute of Medical Sciences jodhpur
Eligibility
Inclusion criteria
Inclusion criteria: Patients with clinical cervical myelopathy scheduled for elective cervical spine surgery in prone position (Nurick s grade 1-4) 18-65 years of age Ready to consent
Exclusion criteria
Exclusion criteria: Pregnant patients, uncontrolled hypertension, diabetes mellitus, severe cardiac dysfunction, chronic liver and kidney disease, morbid obesity and psychiatric disease. Nurick s grade 0 and 5
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| primary outcome: To compare the incidence of post induction hypotension with propofol versus ketofol in patients with cervical myelopathy posted for cervical spine surgery. Timepoint: at baseline, 2 minutes post induction, post intubation. | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. incidence of hypotension in prone position in two groups. Timepoint: At pre prone, immediately post prone, 5, 10, 15 and 20 minutes post prone position. ;2. Number of episodes of hypotension Timepoint: At baseline, 2 minutes post induction, post intubation, at pre prone, immediately post prone, 5, 10, 15 and 20 minutes post prone position.;3. Number of vasoactive drug doses used Timepoint: At baseline, 2 minutes post induction, post intubation, at pre prone, immediately post prone, 5, 10, 15 and 20 minutes post prone position.;4. time to eye opening, extubation, agitation or delayed recovery. Timepoint: At time of extubation;5. Number of episodes of cerebral desaturation as measured by NIRS Timepoint: At baseline, 2 minutes post induction, post intubation, at pre prone, immediately post prone, 5, 10, 15 and 20 minutes post prone position.;6. Postoperative cognitive function in two groups.Timepoint: Immediate postoperative period | — |
Countries
India
Contacts
Public ContactDr Kirandeep kaur
All India Institute of Medical sciences, Jodhpur
Outcome results
None listed