Comparison between the effectiveness of cryotherapy and purified protein derivative injection in treatment of viral warts

To study the clinical efficacy of cryotherapy versus intralesional purified protein derivative injection in the treatment of cutaneous warts - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/108249

Enrollment

Registered

2026-04-13

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: L088- Other specified local infections of the skin and subcutaneous tissue Health Condition 2: B079- Viral wart, unspecified

Interventions

Intervention1: Cryotherapy: Two freeze thaw cycles of cryotherapy were administered over each wart from a distance of 2 cm for 10 seconds each. Treatment sessions will be repeated every 2 weeks till 8

Eligibility

Inclusion criteria

Inclusion criteria: All consenting patients within age group 12 to 60 years and both gender included Patients with clinically diagnosed cutaneous warts Patients of cutaneous warts with duration of minimum 1 week or maximum 12 months

Exclusion criteria

Exclusion criteria: Patients having warts on face and neck Patients treated for viral wart in last 3 months Pregnant or lactating women Patients having hypersensitivity to PPD antigen Patients with allergic skin disorders or past history of asthma Patients on immunosuppressive therapy Patients having history of any systemic illness Patients diagnosed with cold intolerance or cold urticaria Patients diagnosed with collagen vascular disease Patients diagnosed with Raynaud s phenomenon

Design outcomes

Primary

Measure	Time frame
To compare the clinical efficacy of cryotherapy versus intralesional Purified Protein Derivative (PPD) injection in the treatment of cutaneous wartsTimepoint: 2, 4, 6 and 8 weeks	—

Secondary

Measure	Time frame
To evaluate and compare the safety profiles of both treatments by assessing adverse effects, pain levels, and complications To determine the number of treatment sessions required for complete wart resolution in each groupTimepoint: 2, 4, 6, 8 weeks	—

Countries

India

Contacts

Public ContactDr. Saniya Afzal

Era s Lucknow Medical College and Hospital

drvkoti@gmail.com9246374436

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026