None listed
Conditions
Interventions
Intervention1: Nil: Nil
Intervention2: Nil: Nil
Intervention3: Nil: Nil
Intervention4: Nil: Nil
Sponsors
Indian Council of Medical Research, New Delhi
Eligibility
Inclusion criteria
Inclusion criteria: Gestational age less than 20 weeks at recruitment. Singleton pregnancy. Residing within the study catchment area with plans to stay for at least 2 years. The participants must be willing to provide written informed consent for both their own follow up and that of their child. Infant,At birth follow up Live born infants of enrolled mothers. Gestational age 34 weeks or more at birth. No major congenital anomalies.
Exclusion criteria
Exclusion criteria: Chronic illnesses requiring continuous medical treatment for example, cardiovascular disease, chronic kidney disease. Multiple pregnancies twins or triplets. History of substance abuse for example alcohol, tobacco, illicit drugs. Any condition deemed unsuitable by the investigator for safe participation. Infant At birth and follow up Preterm birth less than 34 weeks. Major congenital anomalies or chromosomal disorders. Severe perinatal complications requiring neonatal ICU stay more than 7 days. Any other condition making follow up assessments impractical for example, relocation outside the study area.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Parameters to be assessed: infant body fat percentage at 1 year of age, measured by the deuterium dilution technique.Timepoint: Time of assessment at 1 year | — |
Secondary
| Measure | Time frame |
|---|---|
| Outcome: Parameters to be assessed: Body composition Hepatic adiposity measured by UGAP Blood biomarkers (insulin, lipids, ALT, hs-CRP) De novo lipogenesis characterisation of the infant at 1 year (subset of 300 infants) Polygenic risk score for metabolic risk Microbiome diversity & compositionTimepoint: Time of assessment at 1 year, Time of assessment for Body composition alone at delivery and at 1 year | — |
Countries
India
Contacts
Public ContactDr Pratibha Dwarkanath
St. Johns Research Institute
Outcome results
None listed