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A comparative study of a new cell-based technique versus traditional iliac bone grafting for bone regeneration in cleft alveolus patients

To Evaluate the Efficacy of Bone Marrow Derived Mononuclear Stem Cells Combined with Platelet Rich Plasma Seeded into Allogenic Bone Graft in Alveolar Bone Grafting in cleft patients A Novel Revolutionary Technique - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108179
Enrollment
30
Registered
2026-04-12
Start date
Unknown
Completion date
Unknown
Last updated
2026-09-14

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: Q351- Cleft hard palate

Interventions

Intervention1: Composite Regenerative Graft (BMMNC + PRP + Allogeneic Bone Graft): The intervention consists of a composite regenerative graft prepared using autologous bone marrow mononuclear cells (

Sponsors

NIL
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients born with alveolar defects including cleft lip and palate Patients age range 5-15years Non syndromic patients Non infectious patients Patients willing to be part of the study

Exclusion criteria

Exclusion criteria: Patients who underwent previous SABG procedure Syndromic patient Patients with uncontrolled systemic diseases Immunocompromised or immune suppressed patients Patients with Cardiac abnormalities Hematologic diseases Paget s disease Osteopetrosis Rickets Any other Bony pathological conditions neoplastic condition Chemotherapy

Design outcomes

Primary

MeasureTime frame
to measure the volume of the newly formed bone to assess the bone density of newly formed boneTimepoint: 6 months

Secondary

MeasureTime frame
PAIN GAIT Timepoint: 5TH DAY - PAIN 1 MONTH - GAIT

Countries

India

Contacts

Public ContactAcchuthaubanyashri

Meenakshi Ammal Dental College And Hospital

drjayanthishyam@gmail.com09003236916

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: Sep 19, 2026