Dental implant after tooth extraction using bone graft

Comparative Evaluation of Immediate Implant Placement Using Recombinant Human Epidermal Growth Factor (rhEGF) with Allograft Versus Allograft Alone: A Randomized Controlled Clinical Trial

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/108121

Enrollment

Registered

2026-04-10

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K081- Complete loss of teeth

Interventions

Intervention1: recombinant human epidermal growth factor(rhEGF) along with allograft in immediate implant: rhEGF has is growth factor which is known to promote bone formation when it is combined with

Eligibility

Inclusion criteria

Inclusion criteria: generally healthy individuals with no medical contraindications for implant surgery healthy soft tissue, indicated by bleeding on probing (BOP) less than 20% and Plaque Index (PI) less than 25% keratinized gingiva minimum 2 mm, both buccally and lingually presence of molar or premolar in the upper or lower jaw (6) implant primary stability minimum 35 Ncm intact remaining alveolar bone walls (buccal bone to be documented) postextraction

Exclusion criteria

Exclusion criteria: smoking (more than equal to 10 cigarettes/day) history of uncontrolled periodontitis uncontrolled diabetes or alcoholism medications known to impair healing implant primary stability less than 35 Ncm.

Design outcomes

Primary

Measure	Time frame
Buccal Bone volumetric change (Preop, immediate post op, 1 year postoperative CBCT) Marginal bone loss(RVG Carestream 6200 using paralleling technique) Bone remodelling (RVG Carestream 6200) Timepoint: Preop, immediate post op, 1 year postoperative	—

Secondary

Measure	Time frame
Comparative Gingival phenotype assessment and volumetric analysis of buccal profile using Intraoral scan(Intraoral soft tissue scan)Timepoint: Preop Immediate postop 1 year postop;Implant Stability ( measured by Resonance Frequency Analyser)Timepoint: Primary stability(immediate post op) secondary stability (during restorative phase);Modified plaque index and Gingival index(mPI and mGI), Probing depth, Keratinised tissue widthTimepoint: Preop and post op(1year);Pink esthetic scoreTimepoint: post restorative post operative(1year);Bone formation markers in peri-implant sulcular fluid: Alkaline phosphataseTimepoint: 07 days post operative 01 month post operative	—

Measure

Time frame

Comparative Gingival phenotype assessment and volumetric analysis of buccal profile using Intraoral scan(Intraoral soft tissue scan)Timepoint: Preop Immediate postop 1 year postop;Implant Stability ( measured by Resonance Frequency Analyser)Timepoint: Primary stability(immediate post op) secondary stability (during restorative phase);Modified plaque index and Gingival index(mPI and mGI), Probing depth, Keratinised tissue widthTimepoint: Preop and post op(1year);Pink esthetic scoreTimepoint: post restorative post operative(1year);Bone formation markers in peri-implant sulcular fluid: Alkaline phosphataseTimepoint: 07 days post operative 01 month post operative

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Countries

India

Contacts

Public ContactDr MANISH RATHI

UNIVERSITY OF DELHI

mnshrathi5@gmail.com9971238331

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026