FindTrial
Sign In

Effect of glycopyrrolate injection in preventing low blood pressure and slow heart rate in patients undergoing lower abdominal surgeries.

EFFICACY OF PROPHYLACTIC INTRAMUSCULAR GLYCOPYRROLATE VERSUS INTRAMUSCULAR NORMAL SALINE IN PREVENTING HYPOTENSION AND BRADYCARDIA IN PATIENTS UNDERGOING ELECTIVE INFRAUMBILICAL SURGERIES UNDER SPINAL ANAESTHESIA. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108055
Enrollment
60
Registered
2026-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: N00-N99- Diseases of the genitourinary system Health Condition 2: M00-M99- Diseases of the musculoskeletal system and connective tissue Health Condition 3: K00-K95- Diseases of the digestive system

Interventions

Intervention1: Intramuscular Glycopyrrolate: Injection Glycopyrrolate 0.2 mg (1 ml) administered intramuscularly in the deltoid muscle 15 minutes prior to spinal anaesthesia. Control Intervention1: In

Sponsors

Dr. Jagriti Saraogi
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients giving consent for participation in the study, surgery and spinal anaesthesia. 2. Patients aged 18 to 65 years. 3. ASA physical status I and II. 4. Scheduled for elective infraumbilical surgeries under spinal anaesthesia.

Exclusion criteria

Exclusion criteria: 1. Patients with known allergy to glycopyrrolate or local anaesthetic. 2. Pregnant patients. 3. Patients with comorbidities like known cardiovascular disease, diabetes, hypertension, COPD, asthma, tuberculosis and glaucoma. 4. Patients with contraindications to spinal anaesthesia like coagulation disorders, spinal deformity, etc.

Design outcomes

Primary

MeasureTime frame
To compare the incidence of hypotension and bradycardia in patients receiving intramuscular glycopyrrolate versus those receiving intramuscular normal saline.Timepoint: From the time of induction of spinal anaesthesia up to 60 mins intraoperatively.—

Secondary

MeasureTime frame
To compare haemodynamic parameters (HR, SBP, DBP, MAP & SpO2) intra-operatively in both groups.Timepoint: Baseline, at induction of spinal anaesthesia and then at an interval of 2 minutes up to 20 minutes and then every 5 minutes up to 60 minutes after the block.;To determine the need for vasopressor support in both groups.Timepoint: From the time of induction of spinal anaesthesia up to 60 minutes intraoperatively.;To assess intraoperative and postoperative side effects like nausea, vomiting and presence of dry mouth in both groups.Timepoint: Intraoperatively and up to 6 hours postoperatively.—

Countries

India

Contacts

Public ContactDr Ajay Kumar Sinha

Government Medical College, Haldwani.

sinhaak1961@gmail.com9897672301

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026