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Evaluating Repetitive Transcranial Magnetic Stimulation as an add-on treatment for Obsessive-Compulsive Disorder

Effectiveness of Repetitive Transcranial Magnetic Stimulation augmentation of pharmacotherapy in Obsessive Compulsive Disorder - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/108005
Enrollment
74
Registered
2026-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: F422- Mixed obsessional thoughts and acts

Interventions

Intervention1: Repetitive Transcranial Magnetic Stimulation: Participants in the intervention arm will receive low-frequency rTMS sessions over the supplementary motor area (SMA) at standard, safety-a

Sponsors

Government Medical College and Hospital
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: 1. Patients aged 18 to 55 years. 2. Diagnosis of Obsessive Compulsive Disorder (OCD) as per ICD-11 criteria. 3. Baseline Yale Brown Obsessive Compulsive Scale (Y-BOCS) score more than or equal to 16 (moderate severity or above). 4. On standard pharmacological treatment (SSRI or clomipramine with or without augmentation with low-dose antipsychotic). 5. Willingness to comply with study procedures and follow-up.

Exclusion criteria

Exclusion criteria: 1. History of epilepsy, seizures, or significant neurological disorder (e.g., stroke, brain tumour, head injury with loss of consciousness). 2. Presence of metallic implants, pacemaker, cochlear implants, or other contraindications to rTMS. 3. Current comorbid psychotic disorder, bipolar disorder, severe personality disorder, suicidal ideation or recent suicide attempt. 4. Active substance use disorder within the past 6 months, patients currently using Benzodiazepines. 5. Severe or uncontrolled medical illnesses (e.g., cardiovascular disease, uncontrolled hypertension, thyroid disorder). 6. Pregnancy or lactation. 7. Patients who have previously received ECT or rTMS treatment for OCD in the previous 6 months.

Design outcomes

Primary

MeasureTime frame
To compare the effectiveness of active Repetitive Transcranial Magnetic Stimulation with standard pharmacotherapy versus sham Repetitive Transcranial Magnetic Stimulation with standard pharmacotherapy in persons with Obsessive Compulsive Disorder.Timepoint: Baseline assessments will be conducted prior to randomization, followed by weekly assessments during the treatment phase and follow-up assessments at 10- and 16-weeks post-baseline.—

Secondary

MeasureTime frame
NILTimepoint: NIL—

Countries

India

Contacts

Public ContactSomya Tuteja

Government Medical College and Hospital, Chandigarh

shivangi02@gmail.com9855784512

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026