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A study comparing bone marrow aspiration concentrate vs own bone graft in single level spinal fusion

Efficacy of bone marrow aspirate concentrate (BMAC) as compared to autograft in achieving spinal fusion in patients undergoing single level transforaminal lumbar interbody fusion (TLIF) - a Pilot RCT

Status
Active, not recruiting
Phases
Phase 1Phase 2
Study type
Interventional
Source
CTRI
Registry ID
CTRI/2026/04/107952
Enrollment
40
Registered
2026-04-09
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: M511- Thoracic, thoracolumbar and lumbosacral intervertebral disc disorders with radiculopathy

Interventions

Intervention1: bone marrow aspirate concentrate: The bone marrow needle assembly, syringes, and filters will be washed with heparin. Eight 10-mL syringes, each containing 1.5 mL of anticoagulant citra
then, the needle was rotated 90 clockwise, and an additional 3 mL will be aspirated. A final 2.5 mL of aspirate is obtained following another 90 of rotation. The first 10-mL syringe is removed and

Sponsors

JIPMER
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18-65 Years Patients undergoing single level TLIF

Exclusion criteria

Exclusion criteria: Previous spinal surgery at the same level Presence of infection or malignancy in the spine Presence of infection or malignancy at the donor site

Design outcomes

Primary

MeasureTime frame
1.To determine the feasibility of achieving spinal fusion using BMAC in patients undergoing single level TLIF 2.To compare the rate of spinal fusion achieved by BMAC and autograft in patients undergoing single level TLIFTimepoint: Initially 6 week post op, followed by 3 months and then 6 months

Secondary

MeasureTime frame
Secondary to compare the rates of the cage migration implant failure infection & reoperation between the groupsTimepoint: Initially 6week post op followed by 3 months & then 6 months

Countries

India

Contacts

Public ContactDr MOHAMMED IRFAN M P

JIPMER, Puducherry

drastos@gmail.com8921352551

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026