Study to Evaluate the Effect of Adding Magnesium Sulphate to Levobupivacaine in blocking Abdominal Nerve for Better Pain Relief After Inguinal Hernia Surgery.

ARandomized Controlled Trial to Evaluate Magnesium Sulphate as an Adjuvant to 0.25 Percent Levobupivacaine in Ultrasound Guided Transversus Abdominis Plane Block for Postoperative Analgesia in Patients Undergoing Unilateral Inguinal Herniorraphy - MAGLEV-TAP Trial

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107938

Enrollment

Registered

2026-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K409- Unilateral inguinal hernia, without obstruction or gangrene

Interventions

Intervention1: Magnesium sulphate with 0.25% Levobupivacaine: Ultrasound-guided TAP block with 0.25% levobupivacaine + magnesium sulphate (dose e.g., 150 250 mg) administered bilaterally for postopera

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged between 18-60 years Patients belonging to American Society Of Anesthesiologist (ASA) physical status grade I II Patients undergoing elective unilateral inguinal hernia surgeries under subarachnoid block

Exclusion criteria

Exclusion criteria: Patients suffering from defect of spinal cord or any anatomical deformity of spine. Patients having infections at the site of injection. Patients with coagulopathy. Patients with prior back surgery. Patients with raised intracranial pressure. Patients with history of cardiac, respiratory,renal or hepatic diseases. Allergy to study medication or local Anaesthetic s.

Design outcomes

Primary

Measure	Time frame
Duration of postoperative analgesia, defined as the time from administration of ultrasound-guided transversus abdominis plane block to the first request for rescue analgesia, measured in hours during the first 24 hours after surgery.Timepoint: Up to 24 hours postoperatively.	—

Secondary

Measure	Time frame
1. To assess postoperative pain scores using the Numeric Pain Rating Scale (NRS/Pain) at predefined time intervals. 2. To evaluate the time to first request for rescue analgesia 3. To compare the total postoperative analgesic (rescue analgesia) consumption within the first 24 hours after surgery. 4. To monitor and compare any adverse effects or complications related to the TAP block or adjuvants used. Timepoint: post-operatively for pain scores and hemodynamic parameters; cumulative rescue analgesic consumption and patient satisfaction assessed at 24 hours; adverse effects monitored during the first 24 hours after surgery.	—

Measure

Time frame

1. To assess postoperative pain scores using the Numeric Pain Rating Scale (NRS/Pain) at predefined time intervals. 2. To evaluate the time to first request for rescue analgesia 3. To compare the total postoperative analgesic (rescue analgesia) consumption within the first 24 hours after surgery. 4. To monitor and compare any adverse effects or complications related to the TAP block or adjuvants used. Timepoint: post-operatively for pain scores and hemodynamic parameters; cumulative rescue analgesic consumption and patient satisfaction assessed at 24 hours; adverse effects monitored during the first 24 hours after surgery.

—

Countries

India

Contacts

Public ContactDr Aashish Dang

Swami Dayanand Hospital

drdangi679@gmail.com9810710458

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026