Healing of Gums After Color Lightening Surgery Using Laser Alone Compared With Laser Plus Healing Gel

A Comparative Evaluation of Photobiomodulation Therapy Alone Versus Photobiomodulation Combined with Hyaluronic Acid Gel on Wound Healing After Surgical Gingival Depigmentation: A Randomized Controlled Clinical Trial - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107920

Enrollment

Registered

2026-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K068- Other specified disorders of gingiva and edentulous alveolar ridge

Interventions

Intervention1: Hyaluronic Acid Application: In Group B, 2% hyaluronic acid gel will be applied topically over the surgical site immediately after PBMT. A fresh perio pack will be then placed to cover

Eligibility

Inclusion criteria

Inclusion criteria: Patients aged 18 45 years Patients with hyperpigmentation score 2 and 3 as per Dummett Oral Pigmentation Index Patients with esthetic concern Patients with good oral hygiene

Exclusion criteria

Exclusion criteria: Patients with systemic diseases like Diabetes mellitus, cardiovascular disorders, immunocompromised condtions Subjects with hypersensitivity to hyaluronic gel or any study materials Previous periodontal surgery or depigmentation in the study area Pregnant or lactating subjects Use of medications influencing pigmentation or wound healing and active periodontal disease or untreated oral infections Subjects with smoking or tobacco habits and unrealistic expectations about treatment Patients undergoing or with a history of chemotherapy or radiotherapy Subjects not willing to participate in the study

Design outcomes

Primary

Measure	Time frame
To evaluate wound healing after surgical gingival depigmentation with photobiomodulation alone and photobiomodulation combined with 2% hyaluronic acid applicationTimepoint: at 3, 7, 14, and 21 days postoperatively	—

Secondary

Measure	Time frame
To evaluate difference in the visual analogue scores after surgical gingival depigmentation with photobiomodulation alone and photobiomodulation combined with 2% hyaluronic acid applicationTimepoint: till 21 days post-operatively;To evaluate the difference in the depigmentation scores after surgical gingival depigmentation with photobiomodulation alone and photobiomodulation combined with 2% hyaluronic acid applicationTimepoint: pre-operatively and 21st day post-operatively	—

Measure

Time frame

To evaluate difference in the visual analogue scores after surgical gingival depigmentation with photobiomodulation alone and photobiomodulation combined with 2% hyaluronic acid applicationTimepoint: till 21 days post-operatively;To evaluate the difference in the depigmentation scores after surgical gingival depigmentation with photobiomodulation alone and photobiomodulation combined with 2% hyaluronic acid applicationTimepoint: pre-operatively and 21st day post-operatively

—

Countries

India

Contacts

Public ContactDr Raghavendra Metri

Maharashtra Institute of Dental Sciences and Research

drrohinibhise@gmail.com9158118232

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026