Comparing Two Routes of putting Eye Drops to see which gives better Pupil Dilation in healthy population

Efficacy of Topical Mydriatic Instillation on the Cornea Versus the Conjunctiva in Pupil Dilation: A Randomized Comparative Academic Study - NIL

Status

Active, not recruiting

Phases

Phase 4

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107912

Enrollment

Registered

2026-04-09

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

None listed

Interventions

Intervention1: Corneal route of administration: Topical mydriatic instillation (A single eye drop of tropicamide 0.8% + phenylephrine 5%) on cornea for right eye and conjunctiva for left eye Control I

Eligibility

Inclusion criteria

Inclusion criteria: Age group more than 18 years Individuals who needs dilated fundus examination as a routine eye check ups and for various other conditions like diabetic retinopathy hypertensive retinopathy and myopia etc

Exclusion criteria

Exclusion criteria: Any history and evidence of ocular trauma ocular surgeries infections uveitis corneal pathology Patients with unilateral or bilateral iris pathology like iris atropy angle closure Peripheral iridoectomy Any abnormalities in pupillary reflex like APD RAPD Adies tonic pupil Male patients with usage of alpha 1 adrenergic receptor antagonist like tamsulosin Anisocoria (more than 0.5 mm differences between two eyes) Narrow angle glaucoma Patients with severe systemic illnesses

Design outcomes

Primary

Measure	Time frame
Maximum Pupil dilatation measurementTimepoint: 15 min, 30 min and 45 min	—

Secondary

Measure	Time frame
Peak mydriasis, time to peak, patient-reported comfort (VAS score), adverse effects like conjunctival hyperemia, allergic & systemic adverse events like blood pressure & pulse rate derangement, requirement of additional dose. Timepoint: The pupil diameter will be measured at baseline, 15 minutes, 30 minutes & 45 minutes after drug instillation	—

Countries

India

Contacts

Public ContactDr SRINIVASA RAO KATIBOINA

AIIMS Mangalagiri

srinivasa.krishna@aiimsmangalagiri.edu.in8015126827

Outcome results