A Study Comparing Four Medicines Used Inside Root Canals to Kill Bacteria in Children s Teeth of Age 9 13 Years

Comparative Analysis of the Antimicrobial Efficacy of Four Intracanal Medicaments Against Enterococcus faecalis In Permanent Teeth For Endodontic Therapy In Children Aged 9-13 Years: An In Vivo Study - NIL

Status

Active, not recruiting

Phases

Phase 3

Study type

Interventional

Source

CTRI

Registry ID

CTRI/2026/04/107854

Enrollment

Registered

2026-04-08

Start date

Unknown

Completion date

Unknown

Last updated

2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: K044- Acute apical periodontitis of pulpal origin

Interventions

Intervention1: Angelus Bio-C Temp: A commercially available bioceramic intracanal medicament composed of calcium silicates, calcium oxide, calcium tungstate (radiopacifier), titanium oxide, and a non

Eligibility

Inclusion criteria

Inclusion criteria: a) Children in the age group of 9-13 years. b) Healthy children without any systemic disorder. c) Permanent teeth with a closed apex and indicated for root canal therapy.

Exclusion criteria

Exclusion criteria: a) Children below or above the age group of 9 to 13 years. b) Children with history of systemic disorders. c) Permanent teeth with open apex. d) Cracked or fractured permanent tooth.

Design outcomes

Primary

Measure	Time frame
Reduction in Enterococcus faecalis colony-forming units (CFU) after intracanal medicament placementTimepoint: 7 days after placement of intracanal medicament	—

Secondary

Measure	Time frame
Reduction in Enterococcus faecalis CFU after biomechanical preparation.Timepoint: Immediately after biomechanical preparation (same visit) of the root canals.;Comparison of antimicrobial efficacy among the four intracanal medicaments.Timepoint: 7 days after intracanal medicament placement.	—

Countries

India

Contacts

Public ContactDr Brij Kumar

Rungta College of Dental Sciences and Research

brij220787@gmail.com8827800994

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026