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Use of intranasal glyceryl trinitrate spray in emergency treatment of acute heart failure.

Intranasal glyceryl trinitrate in acute heart failure in the emergency department: a series of case observations on feasibility and safety as an emergency resort. - NIL

Status
Active, not recruiting
Phases
Unknown
Study type
Observational
Source
CTRI
Registry ID
CTRI/2026/04/107820
Enrollment
30
Registered
2026-04-07
Start date
Unknown
Completion date
Unknown
Last updated
2026-04-27

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Health Condition 1: I509- Heart failure, unspecified

Interventions

Intervention1: Nil: Nil

Sponsors

MANIPAL EM BYPASS, KOKATA (MEDICA SUPERSPECIALITY HOSPITAL, KOLKATA)
Lead Sponsor

Eligibility

Inclusion criteria

Inclusion criteria: Adults (age 18 years and above) presenting to the Emergency Department with acute heart failure. Systolic BP 110 mm Hg or higher. Received or are candidates for intranasal glyceryl trinitrate spray as an emergency resort by treating clinician. Patient or LAR able to give written consent.

Exclusion criteria

Exclusion criteria: SBP less than 110 mm Hg or cardiogenic shock. Severe aortic stenosis or HOCM. Right ventricular infarction. Use of PDE5 inhibitor within 24 hours (48 hours for tadalafil). Nitrate allergy, nasal obstruction, trauma or epistaxis. Pregnancy or lactation. Age below 18 years. Unable to cooperate or consent.

Design outcomes

Primary

MeasureTime frame
Feasibility and acute safety of intranasal glyceryl trinitrate spray in adults with acute heart failure managed in emergency departmentTimepoint: Baseline and 60 minutes post admission—

Secondary

MeasureTime frame
Short term physiological response after intranasal glyceryl trinitrate useTimepoint: Baseline 15 minutes 30 minutes & 60 minutes post administration—

Countries

India

Contacts

Public ContactDR SHWETA AWASTHI

Manipal EM Bypass, Kolkata (Medica Superspeciality Hospital, Kolkata)

drshwetawasthi@gmail.com7353117974

Outcome results

None listed

Source: CTRI (via WHO ICTRP) · Data processed: May 1, 2026